Pitsavos Christos, Tampourlou Metaxia, Panagiotakos Demosthenes B, Skoumas Yannis, Chrysohoou Christina, Nomikos Tzortzis, Stefanadis Christodoulos
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Rev Diabet Stud. 2007 Summer;4(2):98-104. doi: 10.1900/RDS.2007.4.98. Epub 2007 Aug 10.
To investigate the relationship between low-grade inflammation and several glycemic indices in a population-based sample of men and women.
The ATTICA study is a population-based cohort that randomly enrolled 1514 men and 1528 women (aged >18 years old), stratified by age and gender, from the Greater Athens area, during 2001-2002. Among several characteristics, inflammation markers (high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, homocysteine and amyloid A) and glycemic control indices (fasting blood glucose, insulin, HOMA) were measured in the participants.
The prevalence of diabetes was 7.8% in men and 6.0% in women. The prevalence of impaired fasting glucose (IFG) was 21% in men and 12% in women. Diabetic subjects had 57% higher mean levels of C-reactive protein (p < 0.001), 22% higher mean levels of interleukin-6 (p < 0.001) and 60% higher levels of tumor necrosis factor-alpha (p < 0.001) compared to non-diabetic subjects. Homocysteine and serum amyloid A levels did not show significant differences among groups.
Our study supports a positive association between low-grade inflammation and diabetes in a population-based sample of men and women without any evidence of cardiovascular disease, which is independent of demographic, clinical and lifestyle characteristics, including physical activity and dietary factors.
在一个基于人群的男性和女性样本中，研究低度炎症与几种血糖指标之间的关系。
阿提卡研究是一项基于人群的队列研究，在2001年至2002年期间，从大雅典地区按年龄和性别分层随机招募了1514名男性和1528名女性（年龄>18岁）。在参与者的多项特征中，测量了炎症标志物（高敏C反应蛋白、白细胞介素-6、肿瘤坏死因子-α、同型半胱氨酸和淀粉样蛋白A）和血糖控制指标（空腹血糖、胰岛素、稳态模型评估）。
男性糖尿病患病率为7.8%，女性为6.0%。男性空腹血糖受损（IFG）患病率为21%，女性为12%。与非糖尿病受试者相比，糖尿病受试者的C反应蛋白平均水平高57%（p<0.001），白细胞介素-6平均水平高22%（p<0.001），肿瘤坏死因子-α水平高60%（p<0.001）。同型半胱氨酸和血清淀粉样蛋白A水平在各组之间未显示出显著差异。
我们的研究支持在一个无任何心血管疾病证据的基于人群的男性和女性样本中，低度炎症与糖尿病之间存在正相关，这与人口统计学、临床和生活方式特征（包括身体活动和饮食因素）无关。
