Pastor-Valero María, Fletcher Astrid E, de Stavola Bianca L, Chaqués-Alepúz Vicente
London School of Hygiene and Tropical Medicine, London, UK.
BMC Ophthalmol. 2007 Nov 26;7:18. doi: 10.1186/1471-2415-7-18.
We aimed to investigate the relation between sunlight exposure and risk of cataract.
We carried out a frequency-matched case-control study of 343 cases and 334 controls attending an ophthalmology outpatient clinic at a primary health-care center in a small town near Valencia, Spain. All cases were diagnosed as having a cataract in at least one eye based on the Lens Opacification Classification system (LOCS II). Controls had no opacities in either eye. All cases and controls were interviewed for information on outdoor exposure, "usual" diet, history of severe episodes of diarrhea illness, life-style factors and medical and socio-demographic variables. Blood antioxidant vitamin levels were also analyzed. We used logistic regression models to estimate sex and age-adjusted odds ratios (ORs) by quintiles of years of occupational outdoor exposure, adjusting for potential confounders such as smoking, alcohol consumption, serum antioxidants and education.
No association was found between years of outdoor exposure and risk of cataract. However, exploratory analyses suggested a positive association between years of outdoor exposure at younger ages and risk of nuclear cataract later in life.
Our study does not support an association with cataract and sunlight exposure over adult life.
我们旨在研究阳光暴露与白内障风险之间的关系。
我们在西班牙巴伦西亚附近一个小镇的初级保健中心的眼科门诊，对343例病例和334例对照进行了频率匹配的病例对照研究。所有病例根据晶状体混浊分类系统（LOCS II）被诊断为至少一只眼睛患有白内障。对照者双眼均无混浊。对所有病例和对照者进行访谈，了解户外暴露、“日常”饮食、严重腹泻病史、生活方式因素以及医疗和社会人口统计学变量等信息。还分析了血液中抗氧化维生素水平。我们使用逻辑回归模型，按职业户外暴露年限的五分位数估计性别和年龄调整后的比值比（OR），并对吸烟、饮酒、血清抗氧化剂和教育等潜在混杂因素进行调整。
未发现户外暴露年限与白内障风险之间存在关联。然而，探索性分析表明，年轻时户外暴露年限与晚年核性白内障风险之间存在正相关。
我们的研究不支持成年期阳光暴露与白内障之间存在关联。
