Glund S, Krook A
Section of Integrative Physiology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Acta Physiol (Oxf). 2008 Jan;192(1):37-48. doi: 10.1111/j.1748-1716.2007.01779.x.
Derangements in whole body glucose and lipid metabolism, accompanied by insulin resistance, are key features of obesity and the metabolic syndrome. A role for inflammation as a causative factor is an emerging concept in the field of metabolic disease. Research has centred on identifying important inflammatory markers, and tumour necrosis factor-alpha has been highlighted as a key mediator of insulin resistance, as well as interleukin-6 (IL-6). A parallel ongoing endeavour is the unravelling of molecular mechanisms underlying the beneficial effects of physical exercise on whole body glucose and lipid metabolism. Release of IL-6 from the contracting skeletal muscle has been proposed to be one of the molecular signals promoting the beneficial exercise-induced effects. These two opposing views of IL-6 underscore that the role of IL-6 in whole body physiology is incompletely resolved. This review aims at summarizing the current data on mechanisms by which IL-6 may impact on glucose and lipid metabolism.
全身葡萄糖和脂质代谢紊乱，伴有胰岛素抵抗，是肥胖症和代谢综合征的关键特征。炎症作为一个致病因素，在代谢疾病领域是一个新兴概念。研究集中在识别重要的炎症标志物，肿瘤坏死因子-α已被强调为胰岛素抵抗的关键介质，白细胞介素-6（IL-6）也是如此。一项正在进行的平行研究是揭示体育锻炼对全身葡萄糖和脂质代谢有益作用的分子机制。收缩骨骼肌释放IL-6被认为是促进有益运动诱导效应的分子信号之一。对IL-6的这两种相反观点强调，IL-6在全身生理学中的作用尚未完全明确。本综述旨在总结目前关于IL-6可能影响葡萄糖和脂质代谢机制的数据。
