Smeenk R, Westgeest T, Swaak T
Scand J Rheumatol Suppl. 1985;56:78-92. doi: 10.3109/03009748509102067.
Determination of antinuclear antibodies (ANA) will gain in diagnostic significance if a specific type of ANA can be related to a defined clinical disorder. The past decade has brought us quite a lot of papers dedicated to this subject. Yet, with exception of the DNA/anti-DNA system, observed correlations have remained scarce or contradictory. Also, still little is known about the pathogenic role of ANA. Perhaps more recent approaches using biochemical technologies will provide us with highly purified nuclear antigens necessary to study possible correlations at a more sophisticated level.
如果某种特定类型的抗核抗体（ANA）能够与某种明确的临床病症相关联，那么ANA的检测在诊断上将会更具意义。在过去十年里，我们看到了许多致力于该主题的论文。然而，除了DNA/抗DNA系统外，所观察到的相关性仍然很少或相互矛盾。此外，关于ANA的致病作用我们仍然知之甚少。或许利用生化技术的最新方法将为我们提供高度纯化的核抗原，以便在更精细的层面上研究可能存在的相关性。
