Gupta R C, Laforce F M, Mills D M
J Lab Clin Med. 1976 Aug;88(2):183-93.
Humoral factors, phagocytosis, bactericidal capability, and ultrastructural morphology of blood polymorphonuclear leukocytes were investigated in 10 patients with Felty's syndrome. Five patients had suffered significant bacterial infections in the past two years while five other patients had not had bacterial infections. The patients with infections had higher concentrations of serum cryoglobulins, and their neutrophils contained immunoglobulin inclusions as seen by immunofluorescent and electron microscopy. Additionally, leukocytes from these patients showed decreased ability to kill Staphylococcus aureus and a minor defect in phagocytosis. There was a generalized subcellular disorganization of these inclusion containing neutrophils and a slower than normal release of lysosomes. Several of the above abnormalities may contribute to an increased susceptibility to bacterial infections in patients with Felty's syndrome.
对10例费尔蒂综合征患者的体液因子、吞噬作用、杀菌能力及血液多形核白细胞的超微结构形态进行了研究。5例患者在过去两年中发生过严重细菌感染，而另外5例患者未发生过细菌感染。感染患者的血清冷球蛋白浓度较高，通过免疫荧光和电子显微镜观察发现，他们的中性粒细胞含有免疫球蛋白包涵体。此外，这些患者的白细胞杀灭金黄色葡萄球菌的能力下降，吞噬作用存在轻微缺陷。这些含有包涵体的中性粒细胞存在普遍的亚细胞结构紊乱，溶酶体释放比正常情况缓慢。上述几种异常情况可能导致费尔蒂综合征患者对细菌感染的易感性增加。
