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Adduct formation between the carcinogen N-acetoxy-2-acetylaminofluorene and synthetic polydeoxyribonucleotides.

作者信息

Harvan D J, Hass J R, Lieberman M W

出版信息

Chem Biol Interact. 1977 May;17(2):203-10. doi: 10.1016/0009-2797(77)90085-0.

DOI:10.1016/0009-2797(77)90085-0
PMID:18291
Abstract

The chemical carcinogen N-acetoxy-2-acetylaminofluorene (NA-AAF) was reacted with poly(dG-dC) - poly(dG-dC); poly dG - poly dC; poly(dA-dT) - poly (dA-dT); and poly dA - poly dT under a variety of conditions. Poly (dG-homo GC polymer and 10--20 more reactive the A + T polymers. Lowering the ionic strength increased the extent of reaction, while pH change (8.9 vs. 5.5) had only a small effect. If ionic strength was adjusted so that the two guanine-containing polymers showed equal thermal stability (as judged by Tm) then the alternating copolymer was 7 times as reactive as the homopolymer. In aggreement with previous investigators, the major product was found to be 8-(N-2-fluorenylacetamido) deoxyguanosine.

摘要

相似文献

1
Adduct formation between the carcinogen N-acetoxy-2-acetylaminofluorene and synthetic polydeoxyribonucleotides.
Chem Biol Interact. 1977 May;17(2):203-10. doi: 10.1016/0009-2797(77)90085-0.
2
The formation of acetylaminofluorene adducts in poly(dC-dG) and poly(dA-dT) on reaction with N-acetoxy-2-acetylaminofluorene and the effect of such modification upon the polymers as templates for DNA polymerases.聚（dC-dG）和聚（dA-dT）与N-乙酰氧基-2-乙酰氨基芴反应时乙酰氨基芴加合物的形成以及这种修饰对作为DNA聚合酶模板的聚合物的影响。
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3
Alternative conformations of DNA modified by N-2-acetylaminofluorene.由N-2-乙酰氨基芴修饰的DNA的不同构象
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Conformational changes of poly(dG-dC) . poly(dG-dC) modified by the carcinogen N-acetoxy-N-acetyl-2-aminofluorene.经致癌物N-乙酰氧基-N-乙酰-2-氨基芴修饰的聚（dG-dC）·聚（dG-dC）的构象变化
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Reactivity of B and Z-DNA towards N-acetoxy-2-acetylaminofluorene.B型和Z型DNA对N-乙酰氧基-2-乙酰氨基芴的反应活性。
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Comparison of the reactivity of B-DNA and Z-DNA with two isosteric chemical carcinogens: 2-N,N-acetoxyacetylaminofluorene and 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido-[1,2-a:3',2' -d] imidazole.B-DNA和Z-DNA与两种等排化学致癌物的反应性比较：2-N，N-乙酰氧基乙酰氨基芴和3-N，N-乙酰氧基乙酰氨基-4,6-二甲基二吡啶并-[1,2-a:3',2'-d]咪唑。
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引用本文的文献

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Differential inhibition of rat liver DNA polymerases in vitro by direct-acting carcinogens and the protective effect of a thiol reducing agent.直接作用致癌物对大鼠肝脏DNA聚合酶的体外差异抑制作用及一种巯基还原剂的保护作用。
Biochem J. 1981 Mar 1;193(3):985-90. doi: 10.1042/bj1930985.
2
Conformational changes of poly(dG-dC) . poly(dG-dC) modified by the carcinogen N-acetoxy-N-acetyl-2-aminofluorene.经致癌物N-乙酰氧基-N-乙酰-2-氨基芴修饰的聚（dG-dC）·聚（dG-dC）的构象变化
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3
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多聚（dG-dC）·多聚（dG-dC）的构象：被致癌物N-乙酰氧基-N-乙酰-2-氨基芴和N-羟基-N-2-氨基芴修饰后的情况
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Recognition of chemical carcinogen-modified DNA by a DNA-binding protein.一种DNA结合蛋白对化学致癌物修饰的DNA的识别。
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