• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Conformations of poly(dG-dC).poly(dG-dC) modified by the O-acetyl derivative of the carcinogen 4-hydroxyaminoquinoline 1-oxide.由致癌物4-羟基氨基喹啉1-氧化物的O-乙酰基衍生物修饰的聚（dG-dC）.聚（dG-dC）的构象
Nucleic Acids Res. 1984 Oct 25;12(20):7915-27. doi: 10.1093/nar/12.20.7915.
2
Induction of the Z conformation in poly(dG-dC).poly(dG-dC) by binding of N-2-acetylaminofluorene to guanine residues.N-2-乙酰氨基芴与鸟嘌呤残基结合诱导聚（dG-dC）·聚（dG-dC）形成Z构象。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1451-5. doi: 10.1073/pnas.78.3.1451.
3
Conformational changes of poly(dG-dC) . poly(dG-dC) modified by the carcinogen N-acetoxy-N-acetyl-2-aminofluorene.经致癌物N-乙酰氧基-N-乙酰-2-氨基芴修饰的聚（dG-dC）·聚（dG-dC）的构象变化
Nucleic Acids Res. 1981 Mar 11;9(5):1241-50. doi: 10.1093/nar/9.5.1241.
4
Alternative conformations of DNA modified by N-2-acetylaminofluorene.由N-2-乙酰氨基芴修饰的DNA的不同构象
J Supramol Struct Cell Biochem. 1981;17(3):231-44. doi: 10.1002/jsscb.380170305.
5
Enzymatic methylation of DNA and poly(dG-dC) X poly(dG-dC) modified by 4-acetoxyaminoquinoline-1-oxide, the ultimate carcinogen of 4-nitroquinoline-1-oxide.DNA和经4-乙酰氧基氨基喹啉-1-氧化物（4-硝基喹啉-1-氧化物的最终致癌物）修饰的聚（dG-dC）×聚（dG-dC）的酶促甲基化作用
FEBS Lett. 1983 Oct 31;163(1):85-8. doi: 10.1016/0014-5793(83)81169-7.
6
Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene.多聚（dG-dC）·多聚（dG-dC）的构象：被致癌物N-乙酰氧基-N-乙酰-2-氨基芴和N-羟基-N-2-氨基芴修饰后的情况
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4597-601. doi: 10.1073/pnas.77.8.4597.
7
Spectrophotometrical and immunochemical studies on the conformational changes in poly(dG-dC).poly(dG-dC) after modification by 4-hydroxyaminoquinoline 1-oxide.4-羟基氨基喹啉1-氧化物修饰后聚（dG-dC）·聚（dG-dC）构象变化的分光光度法和免疫化学研究
Biochim Biophys Acta. 1991 Aug 27;1090(1):29-37. doi: 10.1016/0167-4781(91)90033-i.
8
Binding of [(dien)PtCl] Cl to poly(dG-dC)-poly(dG-dC) facilitates the B goes to Z conformational transition.[(二乙三胺)铂氯]氯与聚(dG-dC)-聚(dG-dC)的结合促进了B型到Z型的构象转变。
Nucleic Acids Res. 1982 Jun 11;10(11):3573-88. doi: 10.1093/nar/10.11.3573.
9
The B goes to Z transition of poly(dG-dC) . poly(dG-dC) modified by some platinum derivatives.聚（dG-dC）·聚（dG-dC）经某些铂衍生物修饰后的B到Z转变。
Nucleic Acids Res. 1981 Nov 11;9(21):5659-69. doi: 10.1093/nar/9.21.5659.
10
Circular dichroism of poly(dG-dC) modified by the carcinogens N-methyl-4-aminoazobenzene or 4-aminobiphenyl.经致癌物N-甲基-4-氨基偶氮苯或4-氨基联苯修饰的聚（dG-dC）的圆二色性
Nucleic Acids Res. 1987 Sep 11;15(17):7125-36. doi: 10.1093/nar/15.17.7125.

引用本文的文献

1
The ultimate carcinogen of 4-nitroquinoline 1-oxide does not react with Z-DNA and hyperreacts with B-Z junctions.4-硝基喹啉1-氧化物的最终致癌物不与Z-DNA反应，而与B-Z连接区发生超反应。
Nucleic Acids Res. 1994 Feb 11;22(3):314-20. doi: 10.1093/nar/22.3.314.
2
Polyclonal antibodies to DNA modified with 4-nitroquinoline 1-oxide: application for the detection of 4-nitroquinoline 1-oxide-DNA adducts in vivo.针对经4-硝基喹啉1-氧化物修饰的DNA的多克隆抗体：在体内检测4-硝基喹啉1-氧化物-DNA加合物的应用。
Jpn J Cancer Res. 1988 Feb;79(2):195-203. doi: 10.1111/j.1349-7006.1988.tb01577.x.
3
Activity of carcinogens that bind to the C8 position of guanine residues in an assay specific for the detection of -2 frameshift mutations in a defined hot spot.在一项针对特定热点区域-2移码突变检测的试验中，与鸟嘌呤残基C8位置结合的致癌物活性。
Environ Health Perspect. 1990 Aug;88:83-7. doi: 10.1289/ehp.908883.
4
Induction of -2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues: development of a specific mutation assay.通过与鸟嘌呤残基的C8位结合的致癌物在交替GC序列中诱导-2移码突变：一种特异性突变检测方法的开发
Mol Gen Genet. 1990 May;221(3):331-8. doi: 10.1007/BF00259396.
5
Interaction of RecA protein with pBR322 DNA modified by N-hydroxy-2-acetylaminofluorene and 4-hydroxyaminoquinoline 1-oxide.RecA蛋白与经N-羟基-2-乙酰氨基芴和4-羟基氨基喹啉1-氧化物修饰的pBR322 DNA的相互作用。
Nucleic Acids Res. 1990 May 11;18(9):2707-14. doi: 10.1093/nar/18.9.2707.
6
The 4-nitroquinoline 1-oxide mutational spectrum in single stranded DNA is characterized by guanine to pyrimidine transversions.单链DNA中4-硝基喹啉1-氧化物的突变谱以鸟嘌呤到嘧啶的颠换为特征。
Nucleic Acids Res. 1992 Mar 25;20(6):1283-7. doi: 10.1093/nar/20.6.1283.

本文引用的文献

1
Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene.脱氧鸟苷构象对N - 乙酰化和未乙酰化的2 - 氨基芴在C - 8位结合的敏感性。
Carcinogenesis. 1980;1(11):955-9. doi: 10.1093/carcin/1.11.955.
2
In vitro DNA reaction with a carcinogen: the O,O'-diacetyl-4-hydroxyaminoquinoline 1-oxide changes of stability of modified DNA.致癌物与体外DNA的反应：O，O'-二乙酰-4-羟基氨基喹啉1-氧化物对修饰DNA稳定性的影响
Biochim Biophys Acta. 1980 Oct 17;609(3):383-91. doi: 10.1016/0005-2787(80)90112-4.
3
A transversion mutation hypothesis for chemical carcinogenesis by N2-substitution of guanine in DNA.关于DNA中鸟嘌呤N2位取代导致化学致癌作用的颠换突变假说。
Chem Biol Interact. 1980 Sep;31(3):255-63. doi: 10.1016/0009-2797(80)90014-9.
4
Left-handed DNA helices.左手DNA螺旋
Nature. 1980 Feb 21;283(5749):743-5. doi: 10.1038/283743a0.
5
Adducts from the reaction of O,O'-diacetyl or O-acetyl derivatives of the carcinogen 4-hydroxyaminoquinoline 1-oxide with purine nucleosides.致癌物4-羟基氨基喹啉1-氧化物的O,O'-二乙酰基或O-乙酰基衍生物与嘌呤核苷反应生成的加合物。
Cancer Res. 1981 Nov;41(11 Pt 1):4559-65.
6
Z-DNA conformation of N-2-acetylaminofluorene modified poly(dG-dC).poly(dG-dC) determined by reactivity with anti cytidine antibodies and minimized potential energy calculations.通过与抗胞嘧啶抗体反应及最小化势能计算确定的 N-2-乙酰氨基芴修饰的聚（dG-dC）·聚（dG-dC）的 Z-DNA 构象
Nucleic Acids Res. 1981 Oct 24;9(20):5459-67. doi: 10.1093/nar/9.20.5459.
7
Conformational changes of poly(dG-dC) . poly(dG-dC) modified by the carcinogen N-acetoxy-N-acetyl-2-aminofluorene.经致癌物N-乙酰氧基-N-乙酰-2-氨基芴修饰的聚（dG-dC）·聚（dG-dC）的构象变化
Nucleic Acids Res. 1981 Mar 11;9(5):1241-50. doi: 10.1093/nar/9.5.1241.
8
Conformation of poly(dG-dC) . poly(dG-dC) modified by the carcinogens N-acetoxy-N-acetyl-2-aminofluorene and N-hydroxy-N-2-aminofluorene.多聚（dG-dC）·多聚（dG-dC）的构象：被致癌物N-乙酰氧基-N-乙酰-2-氨基芴和N-羟基-N-2-氨基芴修饰后的情况
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4597-601. doi: 10.1073/pnas.77.8.4597.
9
AAF linked to the guanine amino group: a B-Z junction.AAF与鸟嘌呤氨基相连：一个B-Z连接点。
Nucleic Acids Res. 1983 May 25;11(10):3241-54. doi: 10.1093/nar/11.10.3241.
10
Conformation of 2-aminofluorene-modified DNA.2-氨基芴修饰的DNA的构象
Biopolymers. 1983 Nov;22(11):2423-41. doi: 10.1002/bip.360221109.

由致癌物4-羟基氨基喹啉1-氧化物的O-乙酰基衍生物修饰的聚（dG-dC）.聚（dG-dC）的构象

Conformations of poly(dG-dC).poly(dG-dC) modified by the O-acetyl derivative of the carcinogen 4-hydroxyaminoquinoline 1-oxide.

作者信息

Bailleul B, Galiègue-Zouitina S, Loucheux-Lefebvre M H

出版信息

Nucleic Acids Res. 1984 Oct 25;12(20):7915-27. doi: 10.1093/nar/12.20.7915.

DOI:10.1093/nar/12.20.7915
PMID:6093058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320215/
Abstract

Poly(dG-dC).poly(dG-dC) has been modified by reaction with 4-acetoxyaminoquinoline 1-oxide (Ac-4 HAQO), the ultimate carcinogen of 4-nitroquinoline 1-oxide. The circular dichroism (CD) spectra of the modified and unmodified polymers have been compared under various experimental conditions. The CD spectra were recorded in 1 mM phosphate, 50% (v/v) ethanol, 3.8 M LiCl and 95% (v/v) ethanol, conditions in which poly(dG-dC).poly(dG-dC) adopts the B-, Z-, C- and A-form respectively. In 1 mM phosphate buffer, poly(dG-dC).poly(dG-dC) modified by Ac-4 HAQO seems not to contain regions in the Z-form. Z-form induction could be progressively obtained by the addition of ethanol as follows: in the buffer with about 30% ethanol the modified polymer started to adopt the Z structure, while 40% of ethanol in the buffer was necessary for the unmodified polymer. In the 50% ethanol-1 mM phosphate buffer mixture (v/v), poly(dG-dC).poly(dG-dC) was entirely in the Z-form while poly(dG-dC).poly(dG-dC) modified by Ac-4 HAQO remained partially in the B-form. Enzymatic digestions with the nuclease S1 which is specific of the single-stranded DNA were carried out in order to support the modified poly(dG-dC).poly(dG-dC) CD study conclusions. The role played by the two major adducts on the conformational characteristics of modified polymer is discussed.

摘要

聚（dG-dC）·聚（dG-dC）已通过与4-乙酰氧基氨基喹啉1-氧化物（Ac-4 HAQO）反应进行了修饰，Ac-4 HAQO是4-硝基喹啉1-氧化物的最终致癌物。在各种实验条件下比较了修饰和未修饰聚合物的圆二色性（CD）光谱。CD光谱是在1 mM磷酸盐、50%（v/v）乙醇、3.8 M LiCl和95%（v/v）乙醇中记录的，在这些条件下聚（dG-dC）·聚（dG-dC）分别呈现B型、Z型、C型和A型。在1 mM磷酸盐缓冲液中，经Ac-4 HAQO修饰的聚（dG-dC）·聚（dG-dC）似乎不包含Z型区域。通过添加乙醇可以逐步诱导Z型形成，具体如下：在含有约30%乙醇的缓冲液中，修饰后的聚合物开始呈现Z结构，而未修饰的聚合物则需要缓冲液中40%的乙醇。在50%乙醇-1 mM磷酸盐缓冲液混合物（v/v）中，聚（dG-dC）·聚（dG-dC）完全呈Z型，而经Ac-4 HAQO修饰的聚（dG-dC）·聚（dG-dC）仍部分呈B型。用对单链DNA具有特异性的核酸酶S1进行酶切消化，以支持对修饰后的聚（dG-dC）·聚（dG-dC）的CD研究结论。讨论了两种主要加合物对修饰后聚合物构象特征所起的作用。