Novikoff A B
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2781-7. doi: 10.1073/pnas.73.8.2781.
Enzyme cytochemistry has been used, at the light and electron microscope levels, to "mark" cytoplasmic organelles of mammalian cells. Catalase cytochemistry permitted identification of microperoxisomes, apparently ubiquitous organelles that are attached by numerous slender connections to the endoplasmic reticulum. Thiamine pyrophosphatase and acid phosphatase cytochemistry can be used to distinguish between the Golgi apparatus and a specialized acid-phosphatase-rich region of smooth endoplasmic reticulum (ER) that appears to be involved in: (a) the formation of lysosomes and melanin granules: (b) the processing and packaging of secretory materials in endocrine and exocrine cells; and (c) the metabolism of lipid. The acronym GERL has been given to this region of smooth ER because it is located at the inner or "trans" aspect of the Golgi apparatus and because it appears to produce various types of Lysosomes.
酶细胞化学已在光学显微镜和电子显微镜水平上用于“标记”哺乳动物细胞的细胞质细胞器。过氧化氢酶细胞化学可用于识别微过氧化物酶体，微过氧化物酶体是一种明显普遍存在的细胞器，通过众多细长连接附着在内质网上。硫胺素焦磷酸酶和酸性磷酸酶细胞化学可用于区分高尔基体和富含酸性磷酸酶的光滑内质网（ER）的特殊区域，该区域似乎参与：（a）溶酶体和黑色素颗粒的形成；（b）内分泌和外分泌细胞中分泌物质的加工和包装；以及（c）脂质代谢。由于该光滑内质网区域位于高尔基体的内侧或“反面”，且似乎产生各种类型的溶酶体，因此被赋予了GERL这一缩写。
