Corstjens H, Dicanio D, Muizzuddin N, Neven A, Sparacio R, Declercq L, Maes D
Estée Lauder Companies, Biological Research Department Europe, Nijverheidsstraat 15, 2260 Oevel, Belgium.
Estée Lauder Companies, Melville, NY, USA.
Exp Gerontol. 2008 Jul;43(7):663-667. doi: 10.1016/j.exger.2008.01.012. Epub 2008 Feb 9.
Glycation is the non-enzymatic reaction between reducing sugars and proteins that leads to the formation of advanced glycation end products (AGEs). In vivo skin autofluorescence (lambda(ex)/lambda(em)=370/440 nm) was used as a non-invasive clinical tool to study skin AGE accumulation in healthy panellists. Using multiple linear regression analysis, it was shown that for panellists below the age of 40, glycation associated in vivo skin fluorescence intensity increased as a function of chronological age and body mass index (BMI). Above the age of 40, the fluorescence was associated to age but not to BMI, suggesting that the effect of age became dominant over BMI. Since the accumulation of AGEs is expected to affect the biomechanical properties of the skin, in vivo skin elasticity data were gathered on a second panel. It was found that skin elasticity depended on age and BMI in a similar fashion as to what we observed for the skin fluorescence data. It is hypothesised that skin AGE accumulation contributes to the loss of skin elasticity in aged and/or overweight people.
糖基化是还原糖与蛋白质之间的非酶促反应，会导致晚期糖基化终产物（AGEs）的形成。体内皮肤自发荧光（激发波长/发射波长=370/440纳米）被用作一种非侵入性临床工具，用于研究健康受试者皮肤中AGEs的积累情况。通过多元线性回归分析发现，对于40岁以下的受试者，与糖基化相关的体内皮肤荧光强度随实际年龄和体重指数（BMI）的增加而升高。40岁以上时，荧光与年龄相关，但与BMI无关，这表明年龄的影响超过了BMI。由于预计AGEs的积累会影响皮肤的生物力学特性，因此在另一组受试者中收集了体内皮肤弹性数据。结果发现，皮肤弹性与年龄和BMI的关系，与我们在皮肤荧光数据中观察到的情况类似。据推测，皮肤中AGEs的积累会导致老年人和/或超重人群皮肤弹性的丧失。
