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荷兰针对濒死患者的持续深度镇静:描述性研究。

Continuous deep sedation for patients nearing death in the Netherlands: descriptive study.

作者信息

Rietjens Judith, van Delden Johannes, Onwuteaka-Philipsen Bregje, Buiting Hilde, van der Maas Paul, van der Heide Agnes

机构信息

Department of Public Health, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, Netherlands.

出版信息

BMJ. 2008 Apr 12;336(7648):810-3. doi: 10.1136/bmj.39504.531505.25. Epub 2008 Mar 14.

Abstract

OBJECTIVES

To study the practice of continuous deep sedation in 2005 in the Netherlands and compare it with findings from 2001.

DESIGN

Questionnaire study about random samples of deaths reported to a central death registry in 2005 and 2001.

SETTING

Nationwide physician study in the Netherlands.

PARTICIPANTS

Reporting physicians received a questionnaire about the medical decisions that preceded the patient's death; 78% (n=6860) responded in 2005 and 74% (n=5617) in 2001.

MAIN OUTCOME MEASURES

Characteristics of continuous deep sedation (attending physician, types of patients, drugs used, duration, estimated effect on shortening life, palliative consultation). Requests for euthanasia.

RESULTS

The use of continuous deep sedation increased from 5.6% (95% confidence interval 5.0% to 6.2%) of deaths in 2001 to 7.1% (6.5% to 7.6%) in 2005, mostly in patients treated by general practitioners and in those with cancer (in 2005, 47% of sedated patients had cancer v 33% in 2001). In 83% of cases sedation was induced by benzodiazepines, and in 94% patients were sedated for periods of less than one week until death. Nine per cent of those who received continuous deep sedation had previously requested euthanasia but their requests were not granted. Nine per cent of the physicians had consulted a palliative expert.

CONCLUSIONS

The increased use of continuous deep sedation for patients nearing death in the Netherlands and the limited use of palliative consultation suggests that this practice is increasingly considered as part of regular medical practice.

摘要

目的

研究2005年荷兰持续深度镇静的实施情况,并与2001年的研究结果进行比较。

设计

对2005年和2001年上报至中央死亡登记处的死亡病例随机样本进行问卷调查研究。

地点

荷兰全国范围的医师研究。

参与者

上报医师收到一份关于患者死亡前医疗决策的问卷;2005年的回复率为78%(n = 6860),2001年为74%(n = 5617)。

主要观察指标

持续深度镇静的特征(主治医生、患者类型、使用药物、持续时间、估计对缩短生命的影响、姑息治疗会诊)。安乐死申请情况。

结果

持续深度镇静的使用比例从2001年占死亡病例的5.6%(95%置信区间5.0%至6.2%)增至2005年的7.1%(6.5%至7.6%),主要用于全科医生治疗的患者以及癌症患者(2005年,47%接受镇静的患者患有癌症;而2001年为33%)。在83%的病例中,镇静由苯二氮䓬类药物诱导,94%的患者在死亡前接受镇静的时间少于一周。接受持续深度镇静的患者中有9%此前曾申请安乐死,但请求未获批准。9%的医生曾咨询过姑息治疗专家了解。

结论

在荷兰,对濒死患者使用持续深度镇静的情况增多,且姑息治疗会诊的使用有限,这表明这种做法越来越被视为常规医疗实践的一部分。

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A national guideline for palliative sedation in the Netherlands.荷兰姑息性镇静的国家指南。
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Sedation and expertise in palliative care.姑息治疗中的镇静与专业知识。
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Terminal sedation and euthanasia: a comparison of clinical practices.临终镇静与安乐死:临床实践比较
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