Walker C, Virchow J C, Iff T, Bruijnzeel P L, Blaser K
Schweizerisches Institut für Allergie- und Asthmaforschung, Davos, Switzerland.
Int Arch Allergy Appl Immunol. 1991;94(1-4):241-3.
Abnormalities of peripheral-blood lymphocyte subsets and activation markers were detected in patients with both allergic and nonallergic asthma. Most allergic asthmatics were characterized by increased numbers of IL-2R+ helper T cells and CD23+ B cells. In contrast, nonallergic asthmatics showed increased numbers of IL-2R+ and HLA-DR+ helper and cytotoxic T cells, and a clear redistribution from naive (CD45RA+) to memory (CD45RO+) cells. The number of IL-2R+ T cells correlated with the number of CD23+ B cells in allergic asthma. These changes in the distribution and activation state of T cells suggest an active role for T cells in the pathogenesis of both allergic and nonallergic asthma.
在过敏性和非过敏性哮喘患者中均检测到外周血淋巴细胞亚群和激活标志物异常。大多数过敏性哮喘患者的特征是白细胞介素-2受体（IL-2R）阳性辅助性T细胞和CD23阳性B细胞数量增加。相比之下，非过敏性哮喘患者表现为IL-2R阳性以及人类白细胞抗原-DR（HLA-DR）阳性的辅助性和细胞毒性T细胞数量增加，并且出现从初始（CD45RA阳性）细胞到记忆（CD45RO阳性）细胞的明显重新分布。在过敏性哮喘中，IL-2R阳性T细胞数量与CD23阳性B细胞数量相关。T细胞分布和激活状态的这些变化表明T细胞在过敏性和非过敏性哮喘的发病机制中发挥着积极作用。
