Cermak Rainer
University of Leipzig, Institute of Veterinary Physiology, An den Tierkliniken 7, 04103 Leipzig, Germany.
Expert Opin Drug Metab Toxicol. 2008 Jan;4(1):17-35. doi: 10.1517/17425255.4.1.17.
Flavonoids are a large group of plant polyphenols with presumed beneficial effects on several common diseases. The use of dietary supplements enriched with flavonoids is becoming increasingly popular. These polyphenols are substrates of enzymes like cytochrome P450 monooxygenases and phase II conjugation enzymes, as well as of drug transporters involved in drug excretion. Thus, they share the same metabolic pathways with many therapeutic drugs. A number of studies have demonstrated inhibition of various cytochrome P450 monooxygenases and drug transporters by flavonoids. Flavonoid-induced effects on drug bioavailability were also shown. This raises concerns about the safe use of flavonoid supplements and flavonoid-containing remedies which are not subject to legal regulations. The challenge is to find a suitable way to predict harmful drug-flavonoid interactions.
黄酮类化合物是一大类植物多酚，被认为对几种常见疾病具有有益作用。富含黄酮类化合物的膳食补充剂的使用正变得越来越普遍。这些多酚是细胞色素P450单加氧酶和II相缀合酶等酶以及参与药物排泄的药物转运蛋白的底物。因此，它们与许多治疗药物共享相同的代谢途径。多项研究已证明黄酮类化合物可抑制各种细胞色素P450单加氧酶和药物转运蛋白。黄酮类化合物对药物生物利用度的影响也已得到证实。这引发了人们对不受法律法规约束的黄酮类补充剂和含黄酮类药物安全使用的担忧。挑战在于找到一种合适的方法来预测有害的药物 - 黄酮类化合物相互作用。
