Goetze Oliver, Fruehauf Heiko, Pohl Daniel, Giarrè Marianna, Rochat Florence, Ornstein Kurt, Menne Dieter, Fried Michael, Thumshirn Miriam
Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
Br J Nutr. 2008 Nov;100(5):1077-85. doi: 10.1017/S0007114508960918. Epub 2008 Apr 1.
Specific carbohydrates, i.e. prebiotics such as fructo-oligosaccharide (FOS), are not digested in the small intestine but fermented in the colon. Besides beneficial health effects of an enhanced bifidobacteria population, intestinal gas production resulting from fermentation can induce abdominal symptoms. Partial replacement with slowly fermented acacia gum may attenuate side effects. The aim was to compare the effects of FOS with those of a prebiotic mixture (50 % FOS and 50 % acacia gum; BLEND) and a rapidly absorbed carbohydrate (maltodextrin) on general intestinal wellbeing, abdominal comfort and anorectal sensory function. Twenty volunteers (eight male and twelve female; age 20-37 years) completed this double-blind, randomised study with two cycles of a 2-week run-in phase (10 g maltodextrin) followed by 5 weeks of 10 g FOS or BLEND once daily, separated by a 4-week wash-out interval. Abdominal symptoms and general wellbeing were documented by telephone interview or Internet twice weekly. Rectal sensations were assessed by a visual analogue scale during a rectal barostat test after FOS and BLEND treatment. Both FOS and BLEND induced more side effects than maltodextrin. Belching was more pronounced under FOS compared with BLEND (P = 0.09 for females; P = 0.01 for males), and for self-reported general wellbeing strong sex differences were reported (P = 0.002). Urgency scores during rectal barostat were higher with FOS than BLEND (P = 0.01). Faced with a growing range of supplemented food products, consumers may benefit from prebiotic mixtures which cause fewer abdominal side effects. Sex differences must be taken in consideration when food supplements are used.
特定碳水化合物，即益生元如低聚果糖（FOS），在小肠中不被消化，但在结肠中发酵。除了增加双歧杆菌数量对健康有益外，发酵产生的肠道气体可引发腹部症状。用发酵较慢的阿拉伯胶部分替代可能会减轻副作用。目的是比较FOS、益生元混合物（50% FOS和50%阿拉伯胶；混合制剂）和快速吸收的碳水化合物（麦芽糊精）对一般肠道健康、腹部舒适度和肛门直肠感觉功能的影响。20名志愿者（8名男性和12名女性；年龄20 - 37岁）完成了这项双盲、随机研究，研究包括两个周期，每个周期有2周的导入期（10克麦芽糊精），随后是5周每天一次服用10克FOS或混合制剂，中间间隔4周的洗脱期。通过电话访谈或互联网每周两次记录腹部症状和一般健康状况。在FOS和混合制剂治疗后，通过直肠压力测定试验期间的视觉模拟量表评估直肠感觉。FOS和混合制剂都比麦芽糊精引发更多副作用。与混合制剂相比，FOS导致的嗳气更明显（女性P = 0.09；男性P = 0.01），并且报告的自我感觉一般健康状况存在强烈的性别差异（P = 0.002）。FOS治疗期间直肠压力测定的急迫感评分高于混合制剂（P = 0.01）。面对越来越多的补充食品，消费者可能会从引起较少腹部副作用的益生元混合物中受益。使用食品补充剂时必须考虑性别差异。
