Bernstein Eric F, Kligman Albert
Laser Surgery and Cosmetic Dermatology Centers, Bryn Mawr, Pennsylvania, USA.
Lasers Surg Med. 2008 Apr;40(4):233-9. doi: 10.1002/lsm.20621.
Rosacea results from sun-induced hyper-vascularity of exposed facial skin, often accompanied by acneiform papules and pustules. The pulsed-dye laser has an unparalleled safety record and emits an ideal wavelength for treating the abnormal vessels that occur in rosacea patients. In this study we investigate the ability of the long pulse-duration pulsed-dye laser to improve rosacea.
STUDY DESIGN/MATERIALS AND METHODS: Twenty subjects with rosacea were treated with the high-energy, long pulse-duration pulsed-dye laser. An elliptical spot and long pulse-duration was used to spot-treat linear telangiectasias, while a circular spot and short pulse-duration was used to treat the entire face. Improvement was determined by blinded evaluation of photographs and by the treating physician's subjective evaluation, before and 8 weeks following the final treatment.
The average rosacea score as estimated by the treating physician decreased from 2.7+/-1.1 to 1.4+ 0.7 (mean+SD) on a 0-6 scale with 0 representing no rosacea and 6 representing the most severe rosacea (P<0.001 level). The average rosacea score as rated by blinded physician observers scoring digital photos was 2.3+/-1.3 before treatment and 1.4+/-0.9 8 weeks following treatment, using a 0 (mild) to 6 (severe) scale.
The high-energy, long pulse-duration pulsed-dye laser improves rosacea with a very favorable safety profile, and less purpura than resulted from earlier generation pulsed-dye lasers.
酒渣鼻是由阳光引起的面部暴露皮肤血管过度增生所致,常伴有痤疮样丘疹和脓疱。脉冲染料激光具有无与伦比的安全记录,并且能发射出理想波长用于治疗酒渣鼻患者出现的异常血管。在本研究中,我们调查了长脉冲持续时间的脉冲染料激光改善酒渣鼻的能力。
研究设计/材料与方法:20名酒渣鼻患者接受了高能量、长脉冲持续时间的脉冲染料激光治疗。使用椭圆形光斑和长脉冲持续时间对线性毛细血管扩张进行点状治疗,而使用圆形光斑和短脉冲持续时间对整个面部进行治疗。通过在最后一次治疗前和治疗后8周对照片进行盲法评估以及治疗医生的主观评估来确定改善情况。
治疗医生估计的酒渣鼻平均评分在0至6分的量表上从2.7±1.1降至1.4±0.7(均值±标准差),其中0表示无酒渣鼻,6表示最严重的酒渣鼻(P<0.001水平)。使用0(轻度)至6(重度)的量表,由盲法医生观察者对数码照片评分得出的酒渣鼻平均评分在治疗前为2.3±1.3,治疗后8周为1.4±0.9。
高能量、长脉冲持续时间的脉冲染料激光能改善酒渣鼻,安全性良好,且紫癜比早期一代脉冲染料激光引起的更少。