Chien Chih-Ching, Tsai Mei-Ling, Chen Chin-Chu, Chang Shing-Jyh, Tseng Ching-Hui
Graduate School of Biotechnology and Bioengineering, Yuan Ze University, 135 Yuan-Tung Rd, Chungli, 320, Taiwan.
Mycopathologia. 2008 Aug;166(2):117-20. doi: 10.1007/s11046-008-9128-x. Epub 2008 May 6.
The inhibitory effects on tyrosinase activity by extracts of several mushrooms belonging to Basidiomycetes were evaluated. Among the tested mushrooms (Ganoderma lucidum, Antrodia camphorata, Agaricus brasiliensis, and Cordyceps militaris), G. lucidum exhibited significant inhibition of tyrosinase activity (IC(50) value 0.32 mg/ml), compared to those prepared from other Basidiomycetes. Tyrosinase inhibitors are effective components of skin-lightening compounds and other cosmetics; currently many of the facial mask cosmetics in the market contain Ganoderma extracts in their ingredients. The finding that mushroom extracts contain tyrosinase activity inhibition will contribute to better understanding of how their 'healing' properties in various Chinese traditional herbal on skin care products.
评估了几种担子菌纲蘑菇提取物对酪氨酸酶活性的抑制作用。在所测试的蘑菇（灵芝、樟芝、巴西蘑菇和蛹虫草）中，与其他担子菌纲蘑菇制备的提取物相比，灵芝对酪氨酸酶活性表现出显著抑制（IC50值为0.32毫克/毫升）。酪氨酸酶抑制剂是美白化合物和其他化妆品的有效成分；目前市场上许多面膜化妆品的成分中都含有灵芝提取物。蘑菇提取物含有酪氨酸酶活性抑制作用这一发现，将有助于更好地理解它们在各种传统中草药中对护肤品的“治疗”特性。
