Price P, Eddy K S, Papadimitriou J M, Faulkner D L, Shellam G R
Department of Microbiology, University of Western Australia, Nedlands.
Am J Pathol. 1991 Jan;138(1):59-67.
Carditis developed 7 days after the administration of murine cytomegalovirus to neonatal, young adult or aged mice of varying sensitivity to lethal infection with this virus. The inflammation persisted for up to 80 days, but infected myocardial cells were rare and were not seen after day 10. The inflammatory cells comprised macrophages (up to 30%) and T cells (up to 80%), with a high ratio of Lyt2+ to L3T4+ cells throughout. Although the H-2 genotype affects murine cytomegalovirus replication at the level of individual cells, and hence resistance to lethal infection, it did not determine resistance to cardiopathy per se. However BALB/c, BALB.B, and BALB.K mice developed persistent myocarditis regardless of age at infection, and age-related cardiopathy was frequent and severe in infected and uninfected mice. B10 and B10.BR mice also developed myocarditis after neonatal infection, but inflammation resolved rapidly after adult infection and age-related cardiopathy was correspondingly mild. C3H mice exhibited minimal carditis after neonatal or adult infection. However neonatal infection appears to accelerate age-related cardiopathy, which is severe in retired breeders of this strain.
在给对鼠巨细胞病毒致死性感染敏感性不同的新生、年轻成年或老年小鼠接种该病毒7天后，发生了心脏炎。炎症持续长达80天，但感染的心肌细胞很少见，在第10天后就未再见到。炎性细胞包括巨噬细胞（高达30%）和T细胞（高达80%），始终具有较高的Lyt2 +与L3T4 +细胞比例。尽管H - 2基因型在单个细胞水平上影响鼠巨细胞病毒复制，从而影响对致死性感染的抵抗力，但它本身并不能决定对心脏病的抵抗力。然而，BALB/c、BALB.B和BALB.K小鼠无论感染时的年龄如何，都会发生持续性心肌炎，并且在感染和未感染的小鼠中，与年龄相关的心脏病都很常见且严重。B10和B10.BR小鼠在新生期感染后也会发生心肌炎，但成年期感染后炎症迅速消退，与年龄相关的心脏病相应较轻。C3H小鼠在新生期或成年期感染后表现出轻微的心脏炎。然而，新生期感染似乎会加速与年龄相关的心脏病，这种心脏病在该品系的老龄繁殖鼠中很严重。
