Institute of Cancer Research University of Trondheim Norway.
Mediators Inflamm. 1993;2(1):23-5. doi: 10.1155/S096293519300002X.
We examined the compartmentalization of bioactive tumour necrosis factor (TNF) and interleukin 6 (IL-6) to the subarachnoid space and systemic circulation in patients with meningococcal meningitis and septic shock/bacteraemia. In patients with meningitis, median levels of TNF in 31 paired samples of cerebrospinal fluid (CSF) and serum were respectively 783 pg/ml and below detection limit (p < 0.001) and median levels of IL-6 were 150 ng/ml and 0.3 ng/ml (p < 0.0001). In patients with septic shock without meningitis, median levels in paired samples of CSF and serum were respectively below detection limit and 65 pg/ml (not significant, (ns)) (TNF, eleven patients) and 1.3 ng/ml-3 ng/ml (ns) (IL-6, nine patients). The data show that TNF and IL-6 are localized to the subarachnoid space in patients with meningitis although the blood-brain barrier is penetrable to serum proteins. On the other hand, patients with septic shock tend to have cytokines in both serum and CSF.
我们检测了生物活性肿瘤坏死因子（TNF）和白细胞介素 6（IL-6）在脑膜炎奈瑟球菌脑膜炎和感染性休克/菌血症患者中的脑脊髓液（CSF）和全身循环中的区室化分布。在脑膜炎患者中，31 对 CSF 和血清样本中 TNF 的中位数水平分别为 783pg/ml 和检测限以下（p<0.001），IL-6 的中位数水平分别为 150ng/ml 和 0.3ng/ml（p<0.0001）。在无脑膜炎的感染性休克患者中，CSF 和血清配对样本中的中位数水平分别为检测限以下和 65pg/ml（无显著差异，（ns））（TNF，11 例）和 1.3ng/ml-3ng/ml（ns）（IL-6，9 例）。数据表明，尽管血脑屏障可穿透血清蛋白，但 TNF 和 IL-6 在脑膜炎患者中局限于脑脊髓液区室。另一方面，感染性休克患者的血清和 CSF 中均存在细胞因子。
