驾驶配备超声设备的运载车辆。
Driving delivery vehicles with ultrasound.
作者信息
Ferrara Katherine W
机构信息
Department of Biomedical Engineering, 451 Health Sciences Drive, University of California, Davis, CA 95616, USA.
出版信息
Adv Drug Deliv Rev. 2008 Jun 30;60(10):1097-102. doi: 10.1016/j.addr.2008.03.002. Epub 2008 Mar 30.
Abstract
Therapeutic applications of ultrasound have been considered for over 40 years, with the mild hyperthermia and associated increases in perfusion produced by ultrasound harnessed in many of the earliest treatments. More recently, new mechanisms for ultrasound-based or ultrasound-enhanced therapies have been described, and there is now great momentum and enthusiasm for the clinical translation of these techniques. This dedicated issue of Advanced Drug Delivery Reviews, entitled "Ultrasound for Drug and Gene Delivery," addresses the mechanisms by which ultrasound can enhance local drug and gene delivery and the applications that have been demonstrated at this time. In this commentary, the identified mechanisms, delivery vehicles, applications and current bottlenecks for translation of these techniques are summarized.
摘要
超声的治疗应用已被研究了40多年，在许多早期治疗中，人们利用超声产生的轻度热疗以及随之而来的灌注增加。最近，基于超声或超声增强疗法的新机制被相继报道，目前这些技术的临床转化正呈现出巨大的发展势头并引发了广泛关注。本期《高级药物递送评论》的特刊“超声用于药物和基因递送”探讨了超声增强局部药物和基因递送的机制以及目前已得到证实的应用。在这篇评论中，将对这些技术已确定的机制、递送载体、应用以及当前转化过程中的瓶颈进行总结。
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