Freile-Pelegrin Y, Robledo D, Chan-Bacab M J, Ortega-Morales B O
Department of Marine Resources; Cinvestav, Km 6 Carretera Antigua a Progreso, Cordemex, 97310, A.P. 73, Mérida, Yuc., Mexico.
Fitoterapia. 2008 Jul;79(5):374-7. doi: 10.1016/j.fitote.2008.02.006. Epub 2008 Apr 18.
Aqueous and organic extracts of twenty-seven species of marine algae (14 species of Rhodophyta, 5 species of Phaeophyta and 8 species of Chlorophyta) collected from the Gulf of Mexico and Caribbean coast of the Yucatan Peninsula (Mexico) were evaluated for their antileishmanial in vitro activity against Leishmania mexicana promastigote forms. The cytotoxicity of these extracts was also assessed using brine shrimp. Organic extracts from Laurencia microcladia (Rhodophyta), Dictyota caribaea, Turbinaria turbinata and Lobophora variegata (Phaeophyta) possessed promising in vitro activity against L. mexicana promastigotes (LC(50) values ranging from 10.9 to 49.9 microg/ml). No toxicity of algal extracts against Artemia salina was observed with LC50 ranging from 119 to >or=1000 microg/ml. Further studies on bio-guided fractionation, isolation and characterization of pure compounds from these species as well as in vivo experiments are needed and are already in progress.
对从墨西哥湾和尤卡坦半岛（墨西哥）加勒比海岸采集的27种海藻（14种红藻、5种褐藻和8种绿藻）的水提取物和有机提取物进行了评估，以检测其对墨西哥利什曼原虫前鞭毛体形式的体外抗利什曼活性。还使用卤虫评估了这些提取物的细胞毒性。来自微小劳伦藻（红藻）、加勒比网地藻、陀螺马尾藻和杂色环叶藻（褐藻）的有机提取物对墨西哥利什曼原虫前鞭毛体具有良好的体外活性（半数致死浓度值范围为10.9至49.9微克/毫升）。未观察到藻类提取物对卤虫有毒性，半数致死浓度范围为119至≥1000微克/毫升。需要对这些物种的生物导向分级分离、纯化合物的分离和表征以及体内实验进行进一步研究，并且这些研究已经在进行中。
