Mimatsu Kenji, Oida Takatsugu, Kawasaki Atsushi, Kano Hisao, Kuboi Youichi, Aramaki Osamu, Amano Sadao
Department of Surgery, Social Insurance Yokohama Central Hospital, 268 Yamashita-cho Naka-ku Yokohama, Kanagawa 231-8553, Japan.
World J Gastroenterol. 2008 May 28;14(20):3273-5. doi: 10.3748/wjg.14.3273.
Pneumatosis cystoides intestinalis (PCI) is a relatively rare condition characterized by intraluminal gas in the gastrointestinal tract. Several chemotherapeutic agents have been reported to be associated with PCI, although fluorouracil-related PCI is extremely rare. We report a case of a 76-year old man who received adjuvant chemotherapy for rectal cancer with fluorouracil (FU) and leucovorin (LV). After 1 cycle of the treatment, he presented with diarrhea and abdominal pain. Abdominal radiogram revealed the presence of free air under the diaphragm and intramural gas in the intestine. Laparotomy was performed, showing a suspected diagnosis of perforation in the gastrointestinal tract. Intraoperative findings revealed penumatosis of the intestine without evidence of perforation. He was treated supportively and his symptoms improved. In conclusion, we should consider the possibility of PCI occurring in patients with malignancies during chemotherapy treatment.
肠气囊肿症（PCI）是一种相对罕见的疾病，其特征为胃肠道内出现腔内气体。据报道，几种化疗药物与PCI有关，尽管氟尿嘧啶相关的PCI极为罕见。我们报告一例76岁男性患者，他接受了氟尿嘧啶（FU）和亚叶酸钙（LV）辅助化疗以治疗直肠癌。治疗1个周期后，他出现腹泻和腹痛。腹部X线片显示膈下有游离气体，肠道内有壁内气体。进行了剖腹手术，疑似诊断为胃肠道穿孔。术中发现肠道有气囊肿但无穿孔证据。给予支持治疗后，他的症状有所改善。总之，我们应考虑恶性肿瘤患者在化疗期间发生PCI的可能性。
