Joncas J H, Rioux E, Wastiaux J P, Leyritz M, Robillard L, Menezes J
Can Med Assoc J. 1976 Nov 6;115(9):858-60.
Two nasopharyngeal carcinomas of the lymphoepithelioma type and two Burkitt's lymphomas with the characteristic histopathologic features developed in three siblings and one first-degree cousin in a large French-Canadian family. Epstein-Barr virus antibody titres in the two lymphoepithelioma cases but not in the Burkitt's lymphoma cases were, as expected, greatly elevated. HLA typing of the family members failed to disclose HLA antigens A2 and B Sin-2, which have been associated with lymphoepithelioma in Asia. The occurrence, however, of a plasmacytoma in one other first-degree cousin and low serum IgA values in several siblings and cousins suggests the possibility of a genetically determined predisposing B-cell dysfunction in the development of these tumours.
在一个法裔加拿大家庭中，三个兄弟姐妹和一个一级表亲患了两例淋巴上皮瘤型鼻咽癌以及两例具有特征性组织病理学特征的伯基特淋巴瘤。正如预期的那样，两例淋巴上皮瘤病例中的爱泼斯坦-巴尔病毒抗体滴度大幅升高，但伯基特淋巴瘤病例中则未升高。对家庭成员进行的 HLA 分型未发现与亚洲淋巴上皮瘤相关的 HLA 抗原 A2 和 B Sin-2。然而，另一个一级表亲患了浆细胞瘤，几个兄弟姐妹和表亲的血清 IgA 值较低，这表明在这些肿瘤的发生过程中可能存在基因决定的易患 B 细胞功能障碍。
