Silvie Olivier, Mota Maria M, Matuschewski Kai, Prudêncio Miguel
Department of Parasitology, Heidelberg University School of Medicine, Heidelberg, Germany.
Curr Opin Microbiol. 2008 Aug;11(4):352-9. doi: 10.1016/j.mib.2008.06.005.
A hallmark of Plasmodium development inside its mammalian victim is the remarkable restriction to the host species. Adaptation to an intracellular life style in specific target cells is determined by multiple parasite-host interactions. The first line of crosstalk occurs during intradermal sporozoite injection by an Anopheles mosquito. The following expansion in the liver is highly efficient and leads to successful establishment of the parasite population. During the periodic waves of fevers and chills the parasite destroys and re-infects red blood cells. Recent advances in experimental genetics and imaging techniques begin to expose the complex interactions at the changing parasite-host interfaces. Understanding the cellular and molecular mechanisms of target cell recognition, nutrient acquisition, and hijacking of cellular and immune functions may ultimately explain the elaborate biology of a medically important single cell eukaryote.
疟原虫在其哺乳动物宿主体内发育的一个标志是对宿主物种的显著限制。对特定靶细胞内细胞内生活方式的适应是由多种寄生虫与宿主的相互作用决定的。第一轮串扰发生在按蚊将皮内子孢子注入宿主体内时。随后在肝脏中的增殖效率很高，并导致寄生虫种群的成功建立。在周期性的发热和寒战期间，寄生虫会破坏并重新感染红细胞。实验遗传学和成像技术的最新进展开始揭示在不断变化的寄生虫-宿主界面处的复杂相互作用。了解靶细胞识别、营养获取以及细胞和免疫功能劫持的细胞和分子机制，最终可能解释这种具有医学重要性的单细胞真核生物的复杂生物学特性。
