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认知表现和功能能力预测精神分裂症患者的社区独立能力。

Cognitive performance and functional competence as predictors of community independence in schizophrenia.

机构信息

Department of Psychology, York University, Toronto, ON M3J 1P3, Canada.

出版信息

Schizophr Bull. 2010 Mar;36(2):381-7. doi: 10.1093/schbul/sbn095. Epub 2008 Jul 30.

Abstract

Measures of functional competence have been introduced to supplement standard cognitive and neuropsychological evaluations in schizophrenia research and practice. Functional competence comprises skills and abilities that are more relevant to daily life and community adjustment. However, it is unclear whether relevance translates into significantly enhanced prediction of real-world outcomes. The aim of this study was to assess the specific contribution of functional competence in predicting a key aspect of real-world outcome in schizophrenia: community independence. Demographic, clinical, cognitive, and functional competence data were obtained from 127 patients with schizophrenia or schizoaffective disorder and used to predict community independence concurrently and longitudinally after 10 months. Hierarchical regression analyses indicated that demographic, clinical, and cognitive predictors accounted jointly for 35%-38% of the variance in community independence across assessment points. Functional competence data failed to add significantly to this validity. Considered separately from demographic and clinical predictors, cognitive and functional competence data accounted for significant amounts of outcome variance. However, the addition of functional competence to standard cognitive test data yielded a significant increase in validity only for concurrent and not for longitudinal prediction of community independence. The specific real-world validity of functional competence is modest, yielding information that is largely redundant with standard cognitive performance.

摘要

在精神分裂症的研究和实践中,已经引入了功能能力测量来补充标准的认知和神经心理学评估。功能能力包括与日常生活和社区适应更相关的技能和能力。然而,目前尚不清楚相关性是否会显著提高对现实世界结果的预测能力。本研究的目的是评估功能能力在预测精神分裂症现实世界结果的一个关键方面方面的具体贡献:社区独立性。从 127 名精神分裂症或分裂情感障碍患者中获得了人口统计学、临床、认知和功能能力数据,并在 10 个月后同时和纵向预测社区独立性。分层回归分析表明,人口统计学、临床和认知预测因素共同解释了社区独立性在各评估点的 35%-38%的方差。功能能力数据并没有显著增加这种有效性。与人口统计学和临床预测因素分开考虑,认知和功能能力数据解释了大量的结果差异。然而,将功能能力与标准认知测试数据相结合,仅对社区独立性的同时预测而不是纵向预测,才显著提高了有效性。功能能力的具体现实有效性是适度的,提供的信息在很大程度上与标准认知表现重复。

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