Mueller N
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
Cancer Causes Control. 1991 Jan;2(1):37-52. doi: 10.1007/BF00052359.
It has been 10 years since the discovery of the human T-cell lymphotropic virus type I (HTLV-I), the first human retrovirus. During the past decade, significant progress has been made in understanding the transmission of the virus and defining its geographic distribution. It has been shown conclusively that HTLV-I is a causal factor in the induction of both adult T-cell leukemia/lymphoma and HTLV-I-associated myelopathy. However, the pathogenesis of each of these conditions is not clear, and in the light of the evidence of immune dysfunction seen among carriers of the infection, it is likely that other associated diseases will be identified. The challenge in the next decade will be to develop and implement therapeutic interventions among carriers to prevent such diseases as well as to curtail transmission within endemic populations.
自发现人类嗜T细胞病毒I型（HTLV-I）——第一种人类逆转录病毒——以来已有10年。在过去十年中，在了解该病毒的传播及确定其地理分布方面取得了重大进展。已确凿表明，HTLV-I是诱发成人T细胞白血病/淋巴瘤和HTLV-I相关脊髓病的一个病因。然而，这些病症中每种病症的发病机制尚不清楚，鉴于在感染携带者中看到免疫功能障碍的证据，很可能会发现其他相关疾病。未来十年的挑战将是在携带者中开发并实施治疗干预措施，以预防此类疾病，并减少在流行人群中的传播。
