Nichols Ruthann, Egle Jonathan P, Langan Nicholas R, Palmer Gregory C
Biological Chemistry Department, University of Michigan Medical School, Ann Arbor, MI 48109-0606, USA.
Peptides. 2008 Dec;29(12):2128-35. doi: 10.1016/j.peptides.2008.08.010. Epub 2008 Aug 22.
Sulfakinins are myoactive peptides and antifeedant factors. Naturally occurring drosulfakinin I (DSK I; FDDYGHMRFNH(2)) and drosulfakinin II (DSK II; GGDDQFDDYGHMRFNH(2)) contain sulfated or nonsulfated tyrosine. We discovered sDSK II and nsDSK II influenced Drosophila melanogaster larval odor preference. However, sDSK I, nsDSK I, MRFNH(2), and saline did not influence odor preference. We discovered sDSK I and nsDSK I influenced larval locomotion. However, sDSK II, nsDSK II, MRFNH(2), and saline did not influence locomotion. Our novel data suggest distinct mechanisms underlie the effects of DSK I and DSK II peptides on odor preference and locomotion, parameters important to many facets of animal survival.
速激肽是肌活性肽和拒食因子。天然存在的果蝇速激肽I（DSK I；FDDYGHMRFNH₂）和果蝇速激肽II（DSK II；GGDDQFDDYGHMRFNH₂）含有硫酸化或非硫酸化的酪氨酸。我们发现硫酸化果蝇速激肽II（sDSK II）和非硫酸化果蝇速激肽II（nsDSK II）会影响黑腹果蝇幼虫的气味偏好。然而，硫酸化果蝇速激肽I（sDSK I）、非硫酸化果蝇速激肽I（nsDSK I）、MRFNH₂和生理盐水不会影响气味偏好。我们发现sDSK I和nsDSK I会影响幼虫的运动。然而，sDSK II、nsDSK II、MRFNH₂和生理盐水不会影响运动。我们的新数据表明，DSK I和DSK II肽对气味偏好和运动的影响存在不同机制，而这些参数对动物生存的许多方面都很重要。
