Gordon M M, Bopp M J, Easter L, Miller G D, Lyles M F, Houston D K, Nicklas B J, Kritchevsky S B
Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
J Nutr Health Aging. 2008 Oct;12(8):505-9. doi: 10.1007/BF02983202.
To determine whether a hypocaloric diet higher in protein can prevent the loss of lean mass that is commonly associated with weight loss.
An intervention study comparing a hypocaloric diet moderately high in protein to one lower in protein.
Study measurements were taken at the Wake Forest University General Clinical Research Center (GCRC) and Geriatric Research Center (GRC).
Twenty-four post-menopausal, obese women (mean age = 58 +/- 6.6 yrs; mean BMI = 33.0 +/- 3.6 kg/m2).
Two 20-week hypocaloric diets (both reduced by 2800 kcal/wk) were compared: one maintaining dietary protein intake at 30% of total energy intake (1.2-1.5 g/kg/d; HI PROT), and the other maintaining dietary protein intake at 15% of total energy (0.5-0.7 g/kg/d; LO PROT). The GCRC metabolic kitchen provided lunch and dinner meals which the women picked up 3 days per week and ate outside of the clinic.
Body composition, including total body mass, total lean mass, total fat mass, and appendicular lean mass, assessed by dual energy x-ray absorptiometry, was measured before and after the diet interventions.
The HI PROT group lost 8.4 +/- 4.5 kg and the LO PROT group lost 11.4 +/- 3.8 kg of body weight (p = 0.11). The mean percentage of total mass lost as lean mass was 17.3% +/- 27.8% and 37.5% +/- 14.6%, respectively (p = 0.03).
Maintaining adequate protein intake may reduce lean mass losses associated with voluntary weight loss in older women.
确定高蛋白低热量饮食是否能预防通常与体重减轻相关的瘦体重流失。
一项干预性研究，比较高蛋白低热量饮食与低蛋白低热量饮食。
研究测量在维克森林大学综合临床研究中心（GCRC）和老年研究中心（GRC）进行。
24名绝经后肥胖女性（平均年龄 = 58 ± 6.6岁；平均BMI = 33.0 ± 3.6 kg/m²）。
比较两种为期20周的低热量饮食（均减少2800千卡/周）：一种将膳食蛋白质摄入量维持在总能量摄入的30%（1.2 - 1.5克/千克/天；高蛋白组），另一种将膳食蛋白质摄入量维持在总能量的15%（0.5 - 0.7克/千克/天；低蛋白组）。GCRC代谢厨房提供午餐和晚餐，女性每周领取3天并在诊所外食用。
在饮食干预前后，通过双能X线吸收法评估身体成分，包括总体重、总瘦体重、总脂肪量和四肢瘦体重。
高蛋白组体重减轻了8.4 ± 4.5千克，低蛋白组体重减轻了11.4 ± 3.8千克（p = 0.11）。作为瘦体重流失的总体重平均百分比分别为17.3% ± 27.8%和37.5% ± 14.6%（p = 0.03）。
保持充足的蛋白质摄入量可能会减少老年女性因主动减重而导致的瘦体重流失。
