Nooyens Astrid C J, van Gelder Boukje M, Verschuren W M Monique
Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Am J Public Health. 2008 Dec;98(12):2244-50. doi: 10.2105/AJPH.2007.130294. Epub 2008 Oct 15.
We studied the effect of smoking on cognitive decline over a 5-year period at middle age (43 to 70 years).
In the Doetinchem Cohort Study, 1964 men and women in the Netherlands were examined for cognitive function at baseline and 5 years later. The association between smoking status and memory function, speed of cognitive processes, cognitive flexibility, and global cognitive function were assessed.
At baseline, smokers scored lower than never smokers in global cognitive function, speed, and flexibility. At 5-year follow-up, decline among smokers was 1.9 times greater for memory function, 2.4 times greater for cognitive flexibility, and 1.7 times greater for global cognitive function than among never smokers. Among ever smokers, the declines in all cognitive domains were larger with increasing number of pack-years smoked.
Interventions to prevent or stop people from smoking may postpone cognitive decline in middle-aged persons.
我们研究了中年时期(43至70岁)吸烟对5年认知衰退的影响。
在多廷赫姆队列研究中,对荷兰的1964名男性和女性在基线时及5年后进行了认知功能检查。评估了吸烟状况与记忆功能、认知过程速度、认知灵活性和整体认知功能之间的关联。
在基线时,吸烟者在整体认知功能、速度和灵活性方面的得分低于从不吸烟者。在5年随访中,吸烟者的记忆功能衰退比从不吸烟者大1.9倍,认知灵活性衰退大2.4倍,整体认知功能衰退大1.7倍。在曾经吸烟的人群中,所有认知领域的衰退都随着吸烟包年数的增加而更大。
预防或阻止人们吸烟的干预措施可能会延缓中年人的认知衰退。