在一项针对健康非裔美国人和白人成年人的横断面研究中，抗氧化营养素与氧化性DNA损伤之间的关联因种族而异。
Correlates of antioxidant nutrients and oxidative DNA damage differ by race in a cross-sectional study of healthy African American and white adults.
作者信息
Watters Joanne L, Satia Jessie A, Kupper Lawrence L
机构信息
Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA.
出版信息
Nutr Res. 2008 Sep;28(9):565-76. doi: 10.1016/j.nutres.2008.06.005.
Although antioxidant nutrients and oxidative DNA damage have been associated with carcinogenesis, few studies have investigated the factors that influence antioxidant intake and oxidative DNA damage in racially diverse populations. Demographic, behavioral, and diet-related psychosocial correlates of plasma antioxidant (carotenoids, vitamin C, and vitamin E) concentrations and oxidative DNA damage were examined using data from a cross-sectional study of 147 generally healthy, nonsmoking African American and white adults in North Carolina, aged 20 to 45 years. All participants completed self-administered demographic, diet, and health questionnaires and provided semifasting (> or = 6 hours) blood samples. Multivariate regression analyses were computed separately for each race to determine associations between the potential correlates with plasma antioxidant concentrations and oxidative DNA damage, separately. Our findings suggest appreciable differences by race. Only a few factors (age, supplement use, and several psychosocial factors) were associated with antioxidant concentrations in African Americans, whereas these and additional factors, including physical activity, waist circumference, and passive smoke exposure, were associated with antioxidant concentrations in whites. For oxidative DNA damage, passive smoke exposure was significantly associated with oxidative DNA damage in African Americans, and age and alcohol were significant in whites. In addition, the regression models generally explained more of the variance in plasma antioxidant concentrations and oxidative DNA damage in whites than in African Americans. Considering the salient correlates differed by race, this work has important implications for the design and implementation of future research studies investigating antioxidant nutrients and/or oxidative stress, especially those in racially diverse populations.
尽管抗氧化营养素与氧化性DNA损伤都与癌症发生有关，但很少有研究调查在不同种族人群中影响抗氧化剂摄入量和氧化性DNA损伤的因素。利用来自北卡罗来纳州147名年龄在20至45岁之间、总体健康且不吸烟的非裔美国人和白人成年人的横断面研究数据，对血浆抗氧化剂（类胡萝卜素、维生素C和维生素E）浓度以及氧化性DNA损伤的人口统计学、行为学和饮食相关心理社会关联因素进行了研究。所有参与者都完成了自行填写的人口统计学、饮食和健康问卷，并提供了半空腹（≥6小时）血液样本。分别对每个种族进行多变量回归分析，以确定潜在关联因素与血浆抗氧化剂浓度以及氧化性DNA损伤之间的关联。我们的研究结果表明不同种族之间存在明显差异。在非裔美国人中，只有少数因素（年龄、补充剂使用情况以及一些心理社会因素）与抗氧化剂浓度有关，而在白人中，这些因素以及其他因素，包括身体活动、腰围和被动吸烟暴露，都与抗氧化剂浓度有关。对于氧化性DNA损伤，被动吸烟暴露在非裔美国人中与氧化性DNA损伤显著相关，而在白人中年龄和饮酒与之显著相关。此外，回归模型对白人群体血浆抗氧化剂浓度和氧化性DNA损伤方差的解释通常比对非裔美国人群体的解释更多。鉴于显著的关联因素因种族而异，这项工作对于未来研究抗氧化营养素和/或氧化应激的研究设计和实施具有重要意义，尤其是在不同种族人群中的研究。
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