Chung Cecilia P, Titova Dina, Oeser Annette, Randels Margaret, Avalos Ingrid, Milne Ginger L, Morrow Jason D, Stein C Michael
Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232-6602, USA.
Clin Rheumatol. 2009 Apr;28(4):435-8. doi: 10.1007/s10067-008-1072-0. Epub 2008 Dec 17.
Oxidative stress is thought to play a role in the pathogenesis of fibromyalgia. We examined the hypothesis that oxidative stress was increased in patients with fibromyalgia and related to the severity of symptoms. Urinary F(2)-isoprostane excretion was measured in 48 patients with fibromyalgia and compared to those of 96 control subjects. In patients, we examined the association between oxidative stress and symptoms. Patients with fibromyalgia were significantly more symptomatic than control subjects, but urinary F(2)-isoprostane excretion did not differ significantly (2.3+/-1.9 vs. 2.8+/-2.2 ng/mg creatinine, p=0.16). In patients with fibromyalgia, F(2)-isoprostane excretion was associated with fatigue visual analog scale (rho=0.30, p=0.04) but not with pain, quality of life, functional capacity, depression, number of tender points, or overall impact of fibromyalgia. Oxidative stress is not increased in patients with fibromyalgia, but as was previously found in patients with systemic lupus erythematosus, oxidative stress was associated with fatigue.
氧化应激被认为在纤维肌痛的发病机制中起作用。我们检验了这样一个假设：纤维肌痛患者的氧化应激增加，且与症状严重程度相关。对48例纤维肌痛患者测定尿F(2)-异前列腺素排泄量，并与96例对照者进行比较。在患者中，我们研究了氧化应激与症状之间的关联。纤维肌痛患者的症状明显比对照者更严重，但尿F(2)-异前列腺素排泄量无显著差异（2.3±1.9对2.8±2.2 ng/mg肌酐，p=0.16）。在纤维肌痛患者中，F(2)-异前列腺素排泄量与疲劳视觉模拟量表相关（rho=0.30，p=0.04），但与疼痛、生活质量、功能能力、抑郁、压痛点数量或纤维肌痛的总体影响无关。纤维肌痛患者的氧化应激并未增加，但正如先前在系统性红斑狼疮患者中所发现的那样，氧化应激与疲劳相关。
