Budihusodo U, Sulaiman H A, Akbar H N, Lesmana L A, Waspodo A S, Noer H M, Akahane Y, Suzuki H
Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta.
Gastroenterol Jpn. 1991 Jul;26 Suppl 3:196-201. doi: 10.1007/BF02779298.
A total of 545 serum samples were consecutively collected from patients with acute hepatitis, chronic hepatitis, liver cirrhosis, hepatocellular carcinoma, chronic hemodialysis and voluntary blood donors to study the seroepidemiology of HBV and HCV infection in Jakarta. Fourteen out of 243 or 5.8% samples from blood donors were HBsAg-positive, while HCV-antibodies (anti-C100 and/or anti-CP9 and/or anti-CP10) positivity rate was found in 59 out of 243 or 24.3%. Out of 91 donors aged 29 years or younger, 15 (16.5%) donors turned positive for HCV-antibody (-ies), while out of 152 donors aged 30 years or above, 44 (28.9%) donors were anti-HCV-positive, showing a higher HCV-antibody prevalence among higher age group. Among 88 acute hepatitis patients, 33 (37.5%) cases, 10 (11.4%) cases, 15 (17.0%) cases and 30 (34.1%) cases were diagnosed as hepatitis A, hepatitis B, acute exacerbation of HCV carriers, and NANB hepatitis respectively. HCV-antibodies were found in 15 (45.5%) of hepatitis A cases and 6 (40.0%) of acute exacerbation of HBV carrier cases, but found only in 9 (30.0%) of acute NANB hepatitis cases. Positivity rates of HCV-antibodies among 23 chronic hepatitis, 80 liver cirrhosis and 64 hepatocellular carcinoma cases were 78.3%, 75.0% and 65.6% respectively, while 30.4%, 30.0% and 45.3% of the respective groups were positive for HBs antigen. Among 47 hemodialysis cases, 97.9% and 6.4% were positive for HCV antibodies and HBs antigen respectively. It was concluded that: (1) HBV infection rate is high among blood donors and patients with acute and chronic liver diseases. (2) HCV infection rate is high among blood donors.(ABSTRACT TRUNCATED AT 250 WORDS)
为研究雅加达地区乙肝病毒（HBV）和丙肝病毒（HCV）感染的血清流行病学，我们连续收集了545份血清样本，样本来自急性肝炎、慢性肝炎、肝硬化、肝细胞癌患者、慢性血液透析患者及自愿献血者。243份献血者样本中有14份（5.8%）HBsAg呈阳性，而243份样本中有59份（24.3%）丙肝抗体（抗-C100和/或抗-CP9和/或抗-CP10）呈阳性。在91名29岁及以下的献血者中，15名（16.5%）丙肝抗体呈阳性，而在152名30岁及以上的献血者中，44名（28.9%）抗-HCV呈阳性，表明较高年龄组的丙肝抗体患病率更高。88名急性肝炎患者中，分别有33例（37.5%）、10例（11.4%）、15例（17.0%）和30例（34.1%）被诊断为甲型肝炎、乙型肝炎、HCV携带者急性加重和非甲非乙型肝炎。15例（45.5%）甲型肝炎病例和6例（40.0%）HBV携带者急性加重病例检测到丙肝抗体，但急性非甲非乙型肝炎病例中仅9例（30.0%）检测到。23例慢性肝炎、80例肝硬化和64例肝细胞癌病例中丙肝抗体阳性率分别为78.3%、75.0%和65.6%，而各相应组中HBs抗原阳性率分别为30.4%、30.0%和45.3%。47例血液透析病例中，丙肝抗体和HBs抗原阳性率分别为97.9%和6.4%。研究得出结论：（1）献血者以及急慢性肝病患者中HBV感染率较高。（2）献血者中HCV感染率较高。（摘要截选至250字）
