Fouda Abdel-Motaal M, Berika Mohamed Y
Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt.
Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):262-71. doi: 10.1111/j.1742-7843.2008.00363.x. Epub 2009 Jan 20.
Patients with chronic, painful diseases often seek alternative therapy. The purpose of this study was to investigate the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) to ameliorate inflammatory process in rat collagen-induced arthritis. Our results show that Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally starting from the dose of booster immunization and for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction, together with reduction of serum levels of interleukin (IL)-1beta, IL-2, IL-6, tumour necrosis factor-alpha, and anti-CII antibodies. Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior to 2 mg/kg/day of indomethacin at most of the measured parameters. These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis.
患有慢性疼痛疾病的患者常常寻求替代疗法。本研究的目的是调查姜根茎水醇提取物（姜提取物）改善大鼠胶原诱导性关节炎炎症过程的潜力。我们的结果表明，从加强免疫剂量开始，以高于50mg/kg/天的剂量腹腔注射姜提取物并持续26天，可改善临床评分、疾病发生率、关节温度和肿胀以及软骨破坏，同时降低血清白细胞介素（IL）-1β、IL-2、IL-6、肿瘤坏死因子-α和抗CII抗体的水平。此外，在大多数测量参数方面，200mg/kg/天剂量的姜提取物优于2mg/kg/天的吲哚美辛。这些观察结果可能使姜提取物成为类风湿性关节炎患者非甾体抗炎药的良好替代品。
