Brass Marcel, Wenke Dorit, Spengler Stephanie, Waszak Florian
Department of Experimental Psychology and Ghent Institute for Functional and Metabolic Imaging, Ghent University, 9000 Ghent, Belgium.
J Neurosci. 2009 Feb 11;29(6):1766-72. doi: 10.1523/JNEUROSCI.5259-08.2009.
One of the major evolutionary advances of human primates in the motor domain is their ability to use verbal instructions to guide their behavior. Despite this fundamental role of verbal information for our behavioral regulation, the functional and neural mechanisms underlying the transformation of verbal instructions into efficient behavior are still poorly understood. To gain deeper insights into the motor representation of verbal instructions, we investigated the neural circuits involved in overcoming interference from stimulus- response (S-R) mappings that are merely instructed and S-R mappings that are implemented. Implemented and instructed S-R mappings revealed a partly overlapping pattern of fronto-parietal brain activity when compared with a neutral condition. However, the direct contrast revealed a clear difference with stronger activation for the implemented condition in the ACC, bilateral inferior parietal cortex, the cerebellum and the precentral sulcus. This indicates that instructed S-R mappings share some properties with implemented S-R mappings but that they are lacking the motor-related properties of implemented mappings.
人类灵长类在运动领域的主要进化进展之一是它们能够使用言语指令来指导自己的行为。尽管言语信息对我们的行为调节具有这一基本作用，但将言语指令转化为有效行为的功能和神经机制仍知之甚少。为了更深入地了解言语指令的运动表征，我们研究了涉及克服来自仅被指示的刺激-反应（S-R）映射和已实施的S-R映射干扰的神经回路。与中性条件相比，已实施的和被指示的S-R映射显示出额顶叶脑活动的部分重叠模式。然而，直接对比显示出明显差异，在ACC、双侧下顶叶皮层、小脑和中央前沟中，已实施条件的激活更强。这表明被指示的S-R映射与已实施的S-R映射具有一些共同属性，但它们缺乏已实施映射的运动相关属性。
