Department of Psychology, University of North Carolina at Chapel Hill, Medical Research Bldg A, Chapel Hill, NC 27599-7175, USA.
Eur J Pain. 2010 Jan;14(1):77-82. doi: 10.1016/j.ejpain.2009.01.002. Epub 2009 Feb 12.
Influence of menstrual cycle phase on experimental pain sensitivity in women and on gender differences in pain sensitivity was examined in 48 men and 49 women in response to cold pressor, heat, and ischemic pain. Each woman was tested at three points in their menstrual cycle in randomized order, the early follicular, late follicular, and luteal phases, while men were also tested three times, controlling for number of days between test sessions. Cycle phase was confirmed via serum hormone levels. As expected, women were significantly more sensitive to cold pain (p<.01), to heat pain (p<.0001), and to ischemic pain (p<.01) than men. However, pain perception during each task was not influenced by the menstrual cycle in women, nor did the menstrual cycle influence the magnitude of the gender differences in pain sensitivity. These results indicate that although women are more sensitive to a variety of noxious stimuli than men, menstrual cycle phase does not appear to moderate those differences in healthy men and women.
研究人员在 48 名男性和 49 名女性中考察了月经周期阶段对女性实验性疼痛敏感性以及对疼痛敏感性的性别差异的影响，这些女性和男性分别接受了冷压、热和缺血性疼痛刺激。每位女性在其月经周期的三个时间点以随机顺序接受测试，即卵泡早期、卵泡晚期和黄体期，而男性也接受了三次测试，控制了测试之间的天数。通过血清激素水平来确认周期阶段。正如预期的那样，女性对冷痛（p<.01）、热痛（p<.0001）和缺血性疼痛（p<.01）的敏感性明显高于男性。然而，在每个任务中，女性的疼痛感知不受月经周期的影响，月经周期也不会影响疼痛敏感性的性别差异的程度。这些结果表明，尽管女性对各种有害刺激比男性更敏感，但月经周期阶段似乎不会调节健康男性和女性之间的这些差异。
