临床免疫学综述系列：血管性水肿患者的诊治方法
Clinical Immunology Review Series: An approach to the patient with angio-oedema.
作者信息
Grigoriadou S, Longhurst H J
机构信息
Barts and The London NHS Trust, Royal London Hospital, London, UK.
出版信息
Clin Exp Immunol. 2009 Mar;155(3):367-77. doi: 10.1111/j.1365-2249.2008.03845.x.
Abstract
Angio-oedema is a common reason for attendance at the accident and emergency department and for referral to immunology/allergy clinics. Causative factors should always be sought, but a large proportion of patients have the idiopathic form of the disease. A minority of patients represent a diagnostic and treatment challenge. Failure to identify the more unusual causes of angio-oedema may result in life-threatening situations. Common and rare causes of angio-oedema will be discussed in this article, as well as the diagnostic and treatment pathways for the management of these patients. A comprehensive history and close monitoring of response to treatment are the most cost-effective diagnostic and treatment tools.
摘要
血管性水肿是患者前往急诊科就诊以及转诊至免疫科/过敏科门诊的常见原因。应始终寻找致病因素，但很大一部分患者患有特发性血管性水肿。少数患者的诊断和治疗颇具挑战性。未能识别出血管性水肿更不常见的病因可能会导致危及生命的情况。本文将讨论血管性水肿的常见和罕见病因，以及这些患者的诊断和治疗途径。全面的病史和对治疗反应的密切监测是最具成本效益的诊断和治疗工具。
相似文献
1
Clinical Immunology Review Series: An approach to the patient with angio-oedema.临床免疫学综述系列：血管性水肿患者的诊治方法
Clin Exp Immunol. 2009 Mar;155(3):367-77. doi: 10.1111/j.1365-2249.2008.03845.x.
2
Misdiagnosis of hereditary angio-oedema type 1 and type 2.1型和2型遗传性血管性水肿的误诊
Br J Dermatol. 2003 Apr;148(4):719-23. doi: 10.1046/j.1365-2133.2003.05231.x.
3
Angio-oedema in dentistry: management of two cases using C1 esterase inhibitor.牙科血管性水肿：使用C1酯酶抑制剂治疗两例病例
Dent Update. 2005 Jul-Aug;32(6):350-2, 354. doi: 10.12968/denu.2005.32.6.350.
4
A case of hereditary angio-oedema type III presenting with C1-inhibitor cleavage and a missense mutation in the F12 gene.一例Ⅲ型遗传性血管性水肿伴C1抑制物裂解及F12基因错义突变。
Br J Dermatol. 2007 May;156(5):1063-5. doi: 10.1111/j.1365-2133.2007.07778.x. Epub 2007 Mar 23.
5
[Hereditary angioedema].[遗传性血管性水肿]
Alergia. 1984 Jan-Mar;31(1):7-11.
6
Hereditary angio-oedema: its pathogenesis and management.遗传性血管性水肿：发病机制与管理
Scott Med J. 1980 Jul;25(3):187-95. doi: 10.1177/003693308002500303.
7
Clinical presentation and diagnosis of hereditary angio-oedema in five families.五个家族中遗传性血管性水肿的临床表现与诊断
S Afr Med J. 1981 Oct 31;60(18):702-6.
8
Clinical practice. Hereditary angioedema.临床实践。遗传性血管性水肿。
N Engl J Med. 2008 Sep 4;359(10):1027-36. doi: 10.1056/NEJMcp0803977.
9
Clinical manifestations, diagnosis, and treatment of hereditary angioedema: survey data from 94 physicians in Japan.遗传性血管性水肿的临床表现、诊断与治疗：来自日本94位医生的调查数据
Ann Allergy Asthma Immunol. 2015 Jun;114(6):492-8. doi: 10.1016/j.anai.2015.03.010. Epub 2015 Apr 11.
10
Hereditary angioneurotic oedema.遗传性血管性水肿
J Laryngol Otol. 1980 Sep;94(9):1075-9. doi: 10.1017/s0022215100089866.
引用本文的文献
1
The characteristics of upper airway edema in hereditary and acquired angioedema with C1-inhibitor deficiency.遗传性和获得性C1抑制物缺乏性血管性水肿的上气道水肿特征
Clin Transl Allergy. 2021 Dec;11(10):e12083. doi: 10.1002/clt2.12083.
2
Angioedema without wheals: a clinical update.无风团性血管性水肿：临床更新。
Balkan Med J. 2021 Mar;38(2):73-81. doi: 10.5152/balkanmedj.2021.20060.
3
Evaluation and Management of Angioedema in the Emergency Department.急诊科血管性水肿的评估与管理。
West J Emerg Med. 2019 Jul;20(4):587-600. doi: 10.5811/westjem.2019.5.42650. Epub 2019 Jul 2.
4
Pathogenesis of Drug Induced Non-Allergic Angioedema: A Review of Unusual Etiologies.药物性非过敏性血管性水肿的发病机制：罕见病因综述
Cureus. 2017 Aug 23;9(8):e1598. doi: 10.7759/cureus.1598.
5
ACE-I Angioedema: Accurate Clinical Diagnosis May Prevent Epinephrine-Induced Harm.血管紧张素转换酶抑制剂（ACE-I）所致血管性水肿：准确的临床诊断可预防肾上腺素引起的伤害。
West J Emerg Med. 2016 May;17(3):283-9. doi: 10.5811/westjem.2016.2.29224. Epub 2016 Apr 26.
6
C1 inhibitor deficiency: 2014 United Kingdom consensus document.C1 抑制剂缺乏症：2014 年英国共识文件。
Clin Exp Immunol. 2015 Jun;180(3):475-83. doi: 10.1111/cei.12584. Epub 2015 May 13.
7
Case Title: 45 year-old male with recurrent angioedema: WAO international case-based discussions.病例标题：45岁复发性血管性水肿男性：世界变态反应组织国际病例讨论
World Allergy Organ J. 2014 Jan 22;7(1):2. doi: 10.1186/1939-4551-7-2.
8
Guidance for diagnosis and treatment of acute angioedema in the emergency department: consensus statement by a panel of Italian experts.急诊科急性血管性水肿诊断与治疗指南：意大利专家小组共识声明
Intern Emerg Med. 2014 Feb;9(1):85-92. doi: 10.1007/s11739-013-0993-z. Epub 2013 Sep 4.
9
The impact of duration of treatment on reported time-to-onset in spontaneous reporting systems for pharmacovigilance.在药物警戒自发报告系统中，治疗持续时间对报告的起始时间的影响。
PLoS One. 2013 Jul 15;8(7):e68938. doi: 10.1371/journal.pone.0068938. Print 2013.
10
Recent developments in the treatment of acute abdominal and facial attacks of hereditary angioedema: focus on human C1 esterase inhibitor.遗传性血管性水肿急性腹部和面部发作治疗的最新进展：聚焦人C1酯酶抑制剂
Appl Clin Genet. 2010 Dec 3;3:133-46. doi: 10.2147/TACG.S9275. Print 2010.
本文引用的文献
1
Pasteurized C1 inhibitor concentrate in hereditary angioedema: pharmacology, safety, efficacy and future directions.巴氏消毒的 C1 抑制剂浓缩物在遗传性血管性水肿中的应用：药理学、安全性、疗效和未来方向。
Expert Rev Clin Immunol. 2008 Jan;4(1):13-20. doi: 10.1586/1744666X.4.1.13.
2
An approach to the patient with urticaria.荨麻疹患者的诊疗方法。
Clin Exp Immunol. 2008 Aug;153(2):151-61. doi: 10.1111/j.1365-2249.2008.03693.x.
3
Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations.遗传性血管性水肿中功能性C1抑制物诊断：检测评估与建议
J Immunol Methods. 2008 Sep 30;338(1-2):14-20. doi: 10.1016/j.jim.2008.06.004. Epub 2008 Jul 23.
4
Rhucin, a recombinant C1 inhibitor for the treatment of hereditary angioedema and cerebral ischemia.鲁新（Rhucin），一种用于治疗遗传性血管性水肿和脑缺血的重组C1抑制剂。
Curr Opin Investig Drugs. 2008 Mar;9(3):310-23.
5
Hereditary angiodema: a current state-of-the-art review, VII: Canadian Hungarian 2007 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema.遗传性血管性水肿：最新技术综述，VII：2007年加拿大匈牙利遗传性血管性水肿诊断、治疗和管理国际共识算法
Ann Allergy Asthma Immunol. 2008 Jan;100(1 Suppl 2):S30-40. doi: 10.1016/s1081-1206(10)60584-4.
6
Hereditary angioedema: a current state-of-the-art review, V: attenuated androgens for the treatment of hereditary angioedema.遗传性血管性水肿：最新技术综述，五：用于治疗遗传性血管性水肿的减毒雄激素
Ann Allergy Asthma Immunol. 2008 Jan;100(1 Suppl 2):S19-22. doi: 10.1016/s1081-1206(10)60582-0.
7
Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema.血管紧张素转换酶抑制剂相关性血管性水肿中的二肽基肽酶IV
Hypertension. 2008 Jan;51(1):141-7. doi: 10.1161/HYPERTENSIONAHA.107.096552. Epub 2007 Nov 19.
8
Hereditary angioedema with normal C1 inhibitor: clinical symptoms and course.C1抑制物正常的遗传性血管性水肿：临床症状与病程
Am J Med. 2007 Nov;120(11):987-92. doi: 10.1016/j.amjmed.2007.08.021.
9
Chronic urticaria: a disease at a crossroad between autoimmunity and coagulation.慢性荨麻疹：一种处于自身免疫与凝血交叉点的疾病。
Autoimmun Rev. 2007 Nov;7(1):71-76. doi: 10.1016/j.autrev.2007.08.002. Epub 2007 Sep 7.
10
Hereditary angioedema with normal C1 inhibitor gene in a family with affected women and men is associated with the p.Thr328Lys mutation in the F12 gene.在一个有男性和女性患者的家族中，C1抑制因子基因正常的遗传性血管性水肿与F12基因中的p.Thr328Lys突变相关。
J Allergy Clin Immunol. 2007 Oct;120(4):975-7. doi: 10.1016/j.jaci.2007.07.002. Epub 2007 Sep 7.
Zotero 插件