Guo Na, Marra Fawziah, Marra Carlo A
Faculty of Pharmaceutical Sciences, Collaboration for Outcomes Research and Evaluation, University of British Columbia, Vancouver, BC, Canada.
Health Qual Life Outcomes. 2009 Feb 18;7:14. doi: 10.1186/1477-7525-7-14.
Tuberculosis remains a major public health problem worldwide. In recent years, increasing efforts have been dedicated to assessing the health-related quality of life experienced by people infected with tuberculosis. The objectives of this study were to better understand the impact of tuberculosis and its treatment on people's quality of life, and to review quality of life instruments used in current tuberculosis research.
A systematic literature search from 1981 to 2008 was performed through a number of electronic databases as well as a manual search. Eligible studies assessed multi-dimensional quality of life in people with tuberculosis disease or infection using standardized instruments. Results of the included studies were summarized qualitatively.
Twelve original studies met our criteria for inclusion. A wide range of quality of life instruments were involved, and the Short-Form 36 was most commonly used. A validated tuberculosis-specific quality of life instrument was not located. The findings showed that tuberculosis had a substantial and encompassing impact on patients' quality of life. Overall, the anti-tuberculosis treatment had a positive effect of improving patients' quality of life; their physical health tended to recover more quickly than the mental well-being. However, after the patients successfully completed treatment and were microbiologically 'cured', their quality of life remained significantly worse than the general population.
Tuberculosis has substantially adverse impacts on patients' quality of life, which persist after microbiological 'cure'. A variety of instruments were used to assess quality of life in tuberculosis and there has been no well-established tuberculosis-specific instrument, making it difficult to fully understand the impact of the illness.
结核病仍然是全球主要的公共卫生问题。近年来，人们越来越致力于评估结核病感染者的健康相关生活质量。本研究的目的是更好地了解结核病及其治疗对人们生活质量的影响，并回顾当前结核病研究中使用的生活质量评估工具。
通过多个电子数据库进行了1981年至2008年的系统文献检索，并进行了手工检索。符合条件的研究使用标准化工具评估结核病患者或感染者的多维生活质量。对纳入研究的结果进行了定性总结。
12项原始研究符合我们的纳入标准。涉及了广泛的生活质量评估工具，其中最常用的是简短健康调查问卷（Short-Form 36）。未找到经过验证的结核病特异性生活质量评估工具。研究结果表明，结核病对患者的生活质量有重大且广泛的影响。总体而言，抗结核治疗对改善患者的生活质量有积极作用；他们的身体健康比心理健康恢复得更快。然而，患者成功完成治疗并在微生物学上“治愈”后，其生活质量仍明显低于一般人群。
结核病对患者的生活质量有重大不利影响，即使在微生物学“治愈”后仍持续存在。在结核病研究中使用了多种工具来评估生活质量，但尚未有完善的结核病特异性工具，这使得难以全面了解该疾病的影响。
