Kakinoki Masashi, Sawada Osamu, Sawada Tomoko, Kawamura Hajime, Ohji Masahito
Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan.
Ophthalmic Surg Lasers Imaging. 2009 Mar-Apr;40(2):135-40. doi: 10.3928/15428877-20090301-09.
To compare macular thicknesses in healthy subjects measured with spectral domain optical coherence tomography (SD-OCT) (Cirrus; Carl Zeiss Meditec, Inc., Dublin, CA) with measurements using time domain (TD-OCT) (Stratus; Carl Zeiss Meditec, Inc.).
Macular thickness was measured five times in the same eye of 10 healthy subjects with both Cirrus and Stratus to assess reliability and then once in the same eye of 50 healthy subjects with both Cirrus and Stratus to compare the average obtained by each device.
Using TD-OCT, the coefficient of variations (CV) of the macular thicknesses within a 1-mm central area ranged from 0.7% to 3.3% (mean, 1.33%); with SD-OCT, the range was 0.2% to 1.3% (mean, 0.66%). The mean CV with SD-OCT was significantly smaller than with TD-OCT (P < .05). The average macular thicknesses with TD-OCT and SD-OCT were 197.2 +/- 17.8 microm and 257.6 +/- 19.6 microm, respectively. However, the correlation was significant (correlation coefficient, 0.916, P<.001).
Cirrus showed better reliability than Stratus. Using SD-OCT, the macula was 60-microm thicker than when measured with TD-OCT. Attention should be given to comparing data obtained using different OCT machines.
比较使用光谱域光学相干断层扫描（SD - OCT）（Cirrus；卡尔蔡司医疗技术公司，加利福尼亚州都柏林）测量的健康受试者黄斑厚度与使用时域（TD - OCT）（Stratus；卡尔蔡司医疗技术公司）测量的结果。
对10名健康受试者的同一只眼睛分别使用Cirrus和Stratus进行黄斑厚度测量，各测量5次以评估可靠性，然后对50名健康受试者的同一只眼睛分别使用Cirrus和Stratus各测量1次，以比较每种设备获得的平均值。
使用TD - OCT时，1毫米中心区域内黄斑厚度的变异系数（CV）范围为0.7%至3.3%（平均为1.33%）；使用SD - OCT时，范围为0.2%至1.3%（平均为0.66%）。SD - OCT的平均CV显著小于TD - OCT（P < 0.05）。TD - OCT和SD - OCT测量的平均黄斑厚度分别为197.2±17.8微米和257.6±19.6微米。然而，相关性显著（相关系数为0.916，P < 0.001）。
Cirrus显示出比Stratus更好的可靠性。使用SD - OCT时，黄斑比使用TD - OCT测量时厚60微米。应注意比较使用不同OCT机器获得的数据。
