Lethbridge Research Centre, Agriculture and Agri-Food Canada, 5403 1st Avenue South, Lethbridge, AB, Canada T1J 4B1.
Michael Smith Laboratories, The University of British Columbia, #301 - 2185 East Mall, Vancouver, B.C., Canada V6T 1Z4.
Int J Mol Sci. 2009 Jan;10(1):147-173. doi: 10.3390/ijms10010147. Epub 2009 Jan 6.
Trichothecenes are sesquiterpenoid mycotoxins associated with fusarium head blight (FHB) of cereals, with worldwide economic and health impacts. While various management strategies have been proposed to reduce the mycotoxin risk, breeding towards FHB-resistance appears to be the most effective means to manage the disease, and reduce trichothecene contamination of cereal-based food products. This review provides a brief summary of the trichothecene synthesis in Fusarium species, their toxicity in plants and humans, followed by the current methods of screening and breeding for resistance to FHB and trichothecene accumulation.
三萜烯类化合物是与禾谷镰刀菌穗枯病（FHB）有关的倍半萜类真菌毒素，对全球的经济和健康都有影响。虽然已经提出了各种管理策略来降低真菌毒素的风险，但培育对 FHB 的抗性似乎是管理这种疾病并减少基于谷物的食品中真菌毒素污染的最有效手段。本文简要概述了镰刀菌属中三萜烯的合成、它们在植物和人类中的毒性，以及目前用于筛选和培育对 FHB 和三萜烯积累抗性的方法。
