Ren Yan, Shen Li, Zhang De-Wu, Dai Sheng-Jun
School of Pharmaceutical Science, Yantai University, Yantai, China.
Chem Pharm Bull (Tokyo). 2009 Apr;57(4):408-10. doi: 10.1248/cpb.57.408.
Two new sesquiterpenoids, lyratol C (1) and lyratol D (2), together with two known sesquiterpenoids, dehydrovomifoliol (3) and blumenol A (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by spectroscopic analyses. In vitro, the four compounds showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.7-8.1 microM.
从白英全草中分离得到两个新的倍半萜类化合物，即裂叶醇C（1）和裂叶醇D（2），以及两个已知的倍半萜类化合物，脱氢催吐萝芙木醇（3）和丁香叶醇A（4）。通过光谱分析确定了它们的结构。在体外，这四种化合物对三种人类癌细胞系，即HONE-1鼻咽癌细胞、KB口腔表皮样癌细胞和HT29结肠癌细胞显示出显著的细胞毒活性，半数抑制浓度（IC50）值在3.7 - 8.1微摩尔范围内。
