角鳞毛蕨中的内酯。

Lactones from Angiopteris caudatiformis.

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.

出版信息

J Nat Prod. 2009 May 22;72(5):921-4. doi: 10.1021/np900027m.

DOI:10.1021/np900027m

PMID:19371069

Abstract

Angiopterlactones A (1) and B (2), two unique lactones, and three known lactones, osmundalactone (3), osmundalin (4), and 3,5-dihydroxy-gamma-caprolactone (5), have been isolated from the rhizome of Angiopteris caudatiformis. The structures of 1 and 2 were determined by NMR and MS methods, and the structure of 2 was confirmed by X-ray crystallography. The absolute configurations of 1 and 2 were assigned by application of the CD excitation chirality method and the modified Mosher's method. Compound 1 was slightly cytotoxic against HeLa cells, with an IC(50) value of 68.8 microM, and compounds 3 and 4 showed moderate insect antifeeding activity against Plutella xylostella and Heliothis virescens.

摘要

从凤尾蕨科植物粗毛凤尾蕨的根茎中分离得到两个独特的内酯化合物羊角扭甙 A（1）和 B（2），以及三个已知内酯化合物，穗花杉双黄酮（3）、穗花杉双黄酮醇（4）和 3,5-二羟基-γ-己内酯（5）。通过 NMR 和 MS 方法确定了 1 和 2 的结构，并通过 X 射线晶体学确证了 2 的结构。通过 CD 激发手性法和改进的 Mosher 法应用，确定了 1 和 2 的绝对构型。化合物 1 对 HeLa 细胞表现出轻微的细胞毒性，IC50 值为 68.8 μM，化合物 3 和 4 对小菜蛾和烟青虫具有中度的昆虫拒食活性。