Jonsson A, Renström F, Lyssenko V, Brito E C, Isomaa B, Berglund G, Nilsson P M, Groop L, Franks P W
Department of Clinical Sciences-Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmö, Sweden.
Diabetologia. 2009 Jul;52(7):1334-8. doi: 10.1007/s00125-009-1355-2. Epub 2009 Apr 17.
AIMS/HYPOTHESIS: Recent reports have suggested that genotypes at the FTO locus interact with physical activity to modify levels of obesity-related traits. We tested this hypothesis in two non-diabetic population-based cohorts, the first from southern Sweden and the second from the Botnia region of western Finland.
In total 2,511 Finnish and 15,925 Swedish non-diabetic middle-aged adults were genotyped for the FTO rs9939609 variant. Physical activity was assessed by questionnaires and standard clinical procedures were conducted, including measures of height and weight and glucose regulation. Tests of gene x physical activity interaction were performed using linear interaction effects to determine whether the effect of this variant on BMI is modified by physical activity.
The minor A allele at rs9939609 was associated with higher BMI in both cohorts, with the per allele difference in BMI being about 0.13 and 0.43 kg/m(2) in the Swedish and Finnish cohorts, respectively (p < 0.0001). The test of interaction between physical activity and the rs9939609 variant on BMI was not statistically significant after controlling for age and sex in either cohort (Sweden: p = 0.71, Finland: p = 0.18).
CONCLUSIONS/INTERPRETATION: The present report does not support the notion that physical activity modifies the effects of the FTO rs9939609 variant on obesity risk in the non-diabetic Swedish or Finnish adults studied here.
目的/假设：最近的报告表明，FTO基因座的基因型与体育活动相互作用，以改变肥胖相关性状的水平。我们在两个基于人群的非糖尿病队列中检验了这一假设，第一个队列来自瑞典南部，第二个队列来自芬兰西部的博特尼亚地区。
对总共2511名芬兰和15925名瑞典非糖尿病中年成年人进行FTO rs9939609变异基因分型。通过问卷调查评估体育活动情况，并进行标准临床检查，包括测量身高、体重和血糖调节情况。使用线性交互效应进行基因×体育活动交互作用测试，以确定体育活动是否会改变该变异对体重指数（BMI）的影响。
在两个队列中，rs9939609位点的次要A等位基因均与较高的BMI相关，在瑞典和芬兰队列中，每个等位基因导致的BMI差异分别约为0.13和0.43kg/m²（p<0.0001）。在两个队列中，在控制年龄和性别后，体育活动与rs9939609变异对BMI的交互作用测试均无统计学意义（瑞典：p=0.71，芬兰：p=0.18）。
结论/解读：本报告不支持体育活动会改变FTO rs9939609变异对本文所研究的非糖尿病瑞典或芬兰成年人肥胖风险影响的观点。
