为有丝分裂而变得圆润且僵硬。
Get round and stiff for mitosis.
作者信息
Théry Manuel, Bornens Michel
出版信息
HFSP J. 2008 Apr;2(2):65-71. doi: 10.2976/1.2895661. Epub 2008 Mar 24.
Abstract
Cell rounding is a common feature of cell division. The spherical shape that cells adopt during mitosis is apparently neither a simple detachment nor a global softening or stiffening that allows cells to adopt what seems to be a mechanical equilibrium. It is a highly complex mechanical transformation by which membrane folding and peripheral signals focusing can match spindle size in order to ensure a proper cell division. Recent new insight into the mechanism involved will prompt the scientific community to focus on the regulation of the physical links that exist between the lipid bilayer membrane and the underlying actin cytoskeleton since it now appears that these will strongly influence some crucial cellular events such as the spatial organization of cell division.
摘要
细胞变圆是细胞分裂的一个常见特征。细胞在有丝分裂期间呈现的球形显然既不是简单的脱离，也不是整体的软化或硬化，而是使细胞达到一种看似机械平衡的状态。这是一种高度复杂的机械转变，通过膜折叠和外周信号聚焦来匹配纺锤体大小，以确保细胞正常分裂。最近对相关机制的新见解将促使科学界关注脂质双分子层膜与下层肌动蛋白细胞骨架之间存在的物理联系的调节，因为现在看来，这些联系将强烈影响一些关键的细胞事件，如细胞分裂的空间组织。
相似文献
1
Get round and stiff for mitosis.为有丝分裂而变得圆润且僵硬。
HFSP J. 2008 Apr;2(2):65-71. doi: 10.2976/1.2895661. Epub 2008 Mar 24.
2
F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.F 肌动蛋白相互作用组揭示波形蛋白作为有丝分裂中肌动蛋白组织和细胞力学的关键调节剂。
Dev Cell. 2020 Jan 27;52(2):210-222.e7. doi: 10.1016/j.devcel.2019.12.011. Epub 2020 Jan 9.
3
The actin cytoskeleton in spindle assembly and positioning.纺锤体组装与定位中的肌动蛋白细胞骨架
Trends Cell Biol. 2009 Apr;19(4):174-9. doi: 10.1016/j.tcb.2009.01.006. Epub 2009 Mar 13.
4
[Rho proteins - the key regulators of cytoskeleton in the progression of mitosis and cytokinesis].[Rho蛋白——有丝分裂和胞质分裂进程中细胞骨架的关键调节因子]
Postepy Hig Med Dosw (Online). 2011 Nov 18;65:704-13. doi: 10.5604/17322693.966197.
5
Exploring the function of cell shape and size during mitosis.探讨有丝分裂过程中细胞形状和大小的功能。
Dev Cell. 2014 Apr 28;29(2):159-69. doi: 10.1016/j.devcel.2014.04.009.
6
A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte.皮质张力的狭窄窗口指导小鼠卵母细胞中不对称纺锤体的定位。
Nat Commun. 2015 Jan 19;6:6027. doi: 10.1038/ncomms7027.
7
Mitosis: moesin and the importance of being round.有丝分裂：膜突蛋白与保持圆形的重要性。
Curr Biol. 2008 Apr 8;18(7):R292-3. doi: 10.1016/j.cub.2008.02.013.
8
Myosin 2-Induced Mitotic Rounding Enables Columnar Epithelial Cells to Interpret Cortical Spindle Positioning Cues.肌球蛋白 2 诱导的有丝分裂胞质环化使柱状上皮细胞能够解读皮质纺锤体定位线索。
Curr Biol. 2017 Nov 6;27(21):3350-3358.e3. doi: 10.1016/j.cub.2017.09.039. Epub 2017 Oct 26.
9
TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.TPPP 通过作用于 RhoA-ROCK-LIMK2 下游来调节星体微管组织和纺锤体方向。
J Cell Sci. 2012 Mar 15;125(Pt 6):1579-90. doi: 10.1242/jcs.096818. Epub 2012 Feb 10.
10
Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis.膜突蛋白在有丝分裂过程中控制皮质硬度、细胞变圆和纺锤体形态发生。
Curr Biol. 2008 Jan 22;18(2):91-101. doi: 10.1016/j.cub.2007.12.051.
引用本文的文献
1
CRIPTO-based micro-heterogeneity of mouse muscle satellite cells enables adaptive response to regenerative microenvironment.基于CRIPTO 的小鼠肌肉卫星细胞的微观异质性使它们能够对再生微环境产生适应性反应。
Dev Cell. 2023 Dec 18;58(24):2896-2913.e6. doi: 10.1016/j.devcel.2023.11.009. Epub 2023 Dec 5.
2
Molecular mechanocytometry using tension-activated cell tagging.利用张力激活细胞标记的分子机械细胞计量学。
Nat Methods. 2023 Nov;20(11):1666-1671. doi: 10.1038/s41592-023-02030-7. Epub 2023 Oct 5.
3
Mitotic outcomes and errors in fibrous environments.纤维环境中的有丝分裂结果和错误。
Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2120536120. doi: 10.1073/pnas.2120536120. Epub 2023 Feb 27.
4
Fine-tuning cell organelle dynamics during mitosis by small GTPases.通过小 GTPases 精细调控有丝分裂期间的细胞器动力学。
Front Med. 2022 Jun;16(3):339-357. doi: 10.1007/s11684-022-0926-1. Epub 2022 Jun 27.
5
Nucleus-Cytoskeleton Crosstalk During Mitotic Entry.有丝分裂进入过程中的细胞核-细胞骨架相互作用
Front Cell Dev Biol. 2021 Mar 18;9:649899. doi: 10.3389/fcell.2021.649899. eCollection 2021.
6
Human mammary epithelial cells in a mature, stratified epithelial layer flatten and stiffen compared to single and confluent cells.与单个细胞和汇合细胞相比，处于成熟分层上皮层中的人乳腺上皮细胞会变扁平且变硬。
Biochim Biophys Acta Gen Subj. 2021 Jun;1865(6):129891. doi: 10.1016/j.bbagen.2021.129891. Epub 2021 Mar 6.
7
Mechanochemical control of epidermal stem cell divisions by B-plexins.机械化学控制表皮干细胞分裂的 B-联蛋白。
Nat Commun. 2021 Feb 26;12(1):1308. doi: 10.1038/s41467-021-21513-9.
8
Two mechanisms drive pronuclear migration in mouse zygotes.两种机制驱动小鼠受精卵的原核迁移。
Nat Commun. 2021 Feb 5;12(1):841. doi: 10.1038/s41467-021-21020-x.
9
Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor.细胞周期蛋白依赖性激酶 1 和 Aurora 激酶共同协调有丝分裂过程中生长因子受体的储存和再分配。
PLoS Biol. 2021 Jan 4;19(1):e3001029. doi: 10.1371/journal.pbio.3001029. eCollection 2021 Jan.
10
Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities.美国工厂使用或生产的各类碳纳米管和纳米纤维的物理化学特性描述及其遗传毒性。
Part Fibre Toxicol. 2020 Dec 7;17(1):62. doi: 10.1186/s12989-020-00392-w.
本文引用的文献
1
Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells.肌动蛋白结合蛋白和其激活激酶Slik是有丝分裂细胞中皮质稳定性和微管组织所必需的。
J Cell Biol. 2008 Feb 25;180(4):739-46. doi: 10.1083/jcb.200709161. Epub 2008 Feb 18.
2
Mammalian cells change volume during mitosis.哺乳动物细胞在有丝分裂期间会改变体积。
PLoS One. 2008 Jan 23;3(1):e1477. doi: 10.1371/journal.pone.0001477.
3
Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis.膜突蛋白在有丝分裂过程中控制皮质硬度、细胞变圆和纺锤体形态发生。
Curr Biol. 2008 Jan 22;18(2):91-101. doi: 10.1016/j.cub.2007.12.051.
4
LIM kinase-mediated cofilin phosphorylation during mitosis is required for precise spindle positioning.有丝分裂期间LIM激酶介导的丝切蛋白磷酸化是精确纺锤体定位所必需的。
J Biol Chem. 2008 Feb 22;283(8):4983-92. doi: 10.1074/jbc.M708644200. Epub 2007 Dec 12.
5
PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.磷脂酰肌醇-3,4,5-三磷酸（PtdIns(3,4,5)P3）调节贴壁细胞中的纺锤体取向。
Dev Cell. 2007 Dec;13(6):796-811. doi: 10.1016/j.devcel.2007.10.014.
6
Life and times of a cellular bleb.细胞气泡的生命与历程
Biophys J. 2008 Mar 1;94(5):1836-53. doi: 10.1529/biophysj.107.113605. Epub 2007 Oct 5.
7
Experimental and theoretical study of mitotic spindle orientation.有丝分裂纺锤体定向的实验与理论研究
Nature. 2007 May 24;447(7143):493-6. doi: 10.1038/nature05786. Epub 2007 May 9.
8
Endosomal recycling controls plasma membrane area during mitosis.内体循环在有丝分裂过程中控制质膜面积。
Proc Natl Acad Sci U S A. 2007 May 8;104(19):7939-44. doi: 10.1073/pnas.0702511104. Epub 2007 May 1.
9
Reassembly of contractile actin cortex in cell blebs.细胞气泡中收缩性肌动蛋白皮层的重组。
J Cell Biol. 2006 Nov 6;175(3):477-90. doi: 10.1083/jcb.200602085.
10
Cell shape and cell division.细胞形状与细胞分裂。
Curr Opin Cell Biol. 2006 Dec;18(6):648-57. doi: 10.1016/j.ceb.2006.10.001. Epub 2006 Oct 12.
Zotero 插件