Théry Manuel, Bornens Michel
HFSP J. 2008 Apr;2(2):65-71. doi: 10.2976/1.2895661. Epub 2008 Mar 24.
Cell rounding is a common feature of cell division. The spherical shape that cells adopt during mitosis is apparently neither a simple detachment nor a global softening or stiffening that allows cells to adopt what seems to be a mechanical equilibrium. It is a highly complex mechanical transformation by which membrane folding and peripheral signals focusing can match spindle size in order to ensure a proper cell division. Recent new insight into the mechanism involved will prompt the scientific community to focus on the regulation of the physical links that exist between the lipid bilayer membrane and the underlying actin cytoskeleton since it now appears that these will strongly influence some crucial cellular events such as the spatial organization of cell division.
细胞变圆是细胞分裂的一个常见特征。细胞在有丝分裂期间呈现的球形显然既不是简单的脱离，也不是整体的软化或硬化，而是使细胞达到一种看似机械平衡的状态。这是一种高度复杂的机械转变，通过膜折叠和外周信号聚焦来匹配纺锤体大小，以确保细胞正常分裂。最近对相关机制的新见解将促使科学界关注脂质双分子层膜与下层肌动蛋白细胞骨架之间存在的物理联系的调节，因为现在看来，这些联系将强烈影响一些关键的细胞事件，如细胞分裂的空间组织。
