Porcine proliferative enteropathy: an important disease with questions remaining to be solved.

Proliferative enteropathy caused by the intracellular bacterium Lawsonia intracellularis is an endemic disease with high herd prevalences reported worldwide. The infection has a considerable impact on pig production and herd economics and, with the development of new diagnostic techniques, L. intracellularis is being identified in an increasing number of pig herds and a wider range of species. This paper reviews current knowledge of the disease, with a focus on the epidemiology in pigs. The prevalence of infection, transmission, predisposing factors, microbial features, pathogenesis, clinical signs, diagnosis, treatment and control are discussed. The disease is mainly controlled by antibiotic treatment and vaccination at herd level. In the development of effective measures to prevent the spread of the infection, increased knowledge of the transmission and persistence of the microorganism are crucial.