Ayers Frederick R, Cuccia David J, Kelly Kristen M, Durkin Anthony J
University of California-Irvine, Beckman Laser Institute, Irvine, California 92612, USA.
Lasers Surg Med. 2009 Aug;41(6):442-53. doi: 10.1002/lsm.20782.
Modulated imaging is a new modality capable of wide-field, spatially resolved measurement of in vivo optical properties. Based on spatial light modulation, the method is inexpensive, non-contact, and allows spatial mapping of tissue absorption and reduced scattering coefficients at any wavelength between 450 and 1,100 nm. Currently, clinicians rely on qualitative visual inspection to guide parameter selection for laser-based tattoo removal. MI provides quantitative measurements of multi-colored tattooed skin which may help guide treatment and objectively assess response.
STUDY DESIGN/MATERIALS AND METHODS: We have measured the spatially varying optical properties of multi-colored tattooed skin over a 50 mm x 50 mm field of view at wavelengths ranging from 650 to 970 nm using MI. These measurements were compared to a similar field of view of non-tattooed skin from an adjacent area.
We have determined the differentiated optical properties in vivo of multi-colored tattooed skin versus non-tattooed skin.
MI provides spatially resolved quantitative information with potential for quantitative assessment of response to treatment and may provide guidance for laser tattoo removal in the future.
调制成像技术是一种新型技术，能够对体内光学特性进行宽视野、空间分辨测量。该方法基于空间光调制，成本低廉、非接触式，并且能够在450至1100纳米之间的任何波长下对组织吸收和约化散射系数进行空间映射。目前，临床医生依靠定性视觉检查来指导基于激光的纹身去除参数选择。调制成像技术可对彩色纹身皮肤进行定量测量，这可能有助于指导治疗并客观评估治疗反应。
研究设计/材料与方法：我们使用调制成像技术在50毫米×50毫米的视野范围内，对波长在650至970纳米之间的彩色纹身皮肤的空间变化光学特性进行了测量。并将这些测量结果与相邻区域未纹身皮肤的类似视野进行了比较。
我们已经确定了彩色纹身皮肤与未纹身皮肤在体内的差异光学特性。
调制成像技术提供了空间分辨的定量信息，具有定量评估治疗反应的潜力，未来可能为激光纹身去除提供指导。
