Bloch B, Bugnon C, Fellman D, Lenys D
Laboratoire de d'Histologie Embryologie Cytogénétique, Faculté Fe Médicine, 2 place Saint Jacques 25030 Besancon Cedex, France.
Neurosci Lett. 1978 Nov;10(1-2):147-52. doi: 10.1016/0304-3940(78)90026-5.
Neurons immunoreactive with anti-beta-endorphin can be detected in the infundibular region of human fetal hypothalami from the 11th week of development. In the human adult, neurons stained with anti-beta-endorphin are located in the infundibular nucleus and are also stained with anti(17-39) ACTH. Their fibers terminate in contact with non/immunoreactive perikarya or close to vessels of the pituitary stalk. The neurons most reactive with anti(17-39)ACTH or anti-beta-endorphin are also immunoreactive with anti-alpha-MSH, anti-beta-MSH, anti-alpha-endorphin, anti(1-24)ACTH or anti-beta-LPH. These results suggest that a molecule similar to pro-opiocortin of fragment(s) of it is secreted by these neurons.
从发育的第11周起，就能在人类胎儿下丘脑的漏斗区检测到与抗β-内啡肽免疫反应的神经元。在成年人中，用抗β-内啡肽染色的神经元位于漏斗核，也能用抗（17-39）促肾上腺皮质激素染色。它们的纤维终止于与非免疫反应性核周体接触处或垂体柄血管附近。对抗（17-39）促肾上腺皮质激素或抗β-内啡肽反应最强的神经元，也与抗α-促黑素、抗β-促黑素、抗α-内啡肽、抗（1-24）促肾上腺皮质激素或抗β-促脂素免疫反应。这些结果表明，这些神经元分泌一种与其前阿黑皮素原分子或其片段相似的分子。
