Son Younsun, Kim Kyungun, Jeon Soeun, Kang Minsoo, Lee Sukho, Park Yoonjung
Department of Health & Human Performance, University of Houston, Houston, TX, USA.
Department of Kinesiology and Health Education, University of Texas, Austin, TX, USA.
Int J Vasc Med. 2017;2017:7532702. doi: 10.1155/2017/7532702. Epub 2017 Oct 1.
The objective of this meta-analysis is to summarize the effect of exercise intervention on flow-mediated dilatation (FMD) in overweight and obese adults. We searched four electronic databases (PubMed/Medline, Scopus, and CINAHL) through June 2016 for relevant studies pertaining to the effectiveness of exercise intervention on FMD. Seventeen of the 91 studies identified met the inclusion criteria. Comprehensive Meta-Analysis software (version 3) was used to compute the standardized mean difference effect size (ES) and 95% CI using a random effects model. We calculated 34 ESs. We found that exercise intervention had medium and positive effects on FMD, with an overall ES of 0.522 (95% CI = 0.257, 0.786). Heterogeneity of ESs was observed ( = 239, ≤ 0.001, = 86.19), and the effect was moderated by comorbidity ( = 6.39, df = 1, = 0.011). A large ES for the combination exercise, low intensity exercise, and comorbidity subgroups (ES = 0.82~1.24) was found. We conclude that while exercise intervention significantly improves FMD in overweight and obese adults, the effect may depend on the different characteristics of exercise intervention and on participants' demographics.
这项荟萃分析的目的是总结运动干预对超重和肥胖成年人血管内皮功能介导的血管舒张（FMD）的影响。我们检索了四个电子数据库（PubMed/Medline、Scopus和CINAHL），截至2016年6月，查找与运动干预对FMD有效性相关的研究。在检索到的91项研究中，有17项符合纳入标准。使用综合荟萃分析软件（版本3），采用随机效应模型计算标准化平均差效应量（ES）和95%置信区间（CI）。我们计算了34个效应量。我们发现运动干预对FMD有中等程度的积极影响，总体效应量为0.522（95%CI = 0.257, 0.786）。观察到效应量存在异质性（Q = 239, P ≤ 0.001, I² = 86.19），且合并症对效应有调节作用（Q = 6.39, df = 1, P = 0.011）。发现联合运动、低强度运动和合并症亚组的效应量较大（ES = 0.82~1.24）。我们得出结论，虽然运动干预能显著改善超重和肥胖成年人的FMD，但其效果可能取决于运动干预的不同特征以及参与者的人口统计学特征。
