Koehler Martin Johannes, Preller Anja, Kindler Nadja, Elsner Peter, König Karsten, Bückle Rainer, Kaatz Martin
Department of Dermatology and Allergology, Friedrich Schiller University, Jena 07743, Germany.
Skin Res Technol. 2009 Aug;15(3):357-63. doi: 10.1111/j.1600-0846.2009.00372.x.
Skin aging is accelerated by extrinsic factors, particularly actinic damage. Over the last decades, both clinical and pathological differences between intrinsic and actinic aging have been characterized. In this work, we aimed at quantifying skin aging by non-invasive in vivo methods.
Young healthy volunteers using indoor tanning facilities and aged people were compared with appropriate controls by measurements of skin elasticity with the Cutometer and the Reviscometer and by semi-quantitative evaluation of the dermal matrix composition by the multiphoton laser tomograph DermaInspect.
We found differences between the sun-protected volar forearm and the dorsal side as well as between young and old test persons with all three methods. No significant differences were found between the skin of indoor-tanned test persons and control. Also, gender had no influence on the severity of skin aging.
The most consistent results were obtained with the DermaInspect. The considerable inter-individual variation due to the cross-sectional design of the study may have disguised the factual skin damage caused by tanning beds.
皮肤老化会因外在因素，尤其是光化损伤而加速。在过去几十年间，已明确了自然老化和光化老化在临床及病理方面的差异。在本研究中，我们旨在通过非侵入性体内方法对皮肤老化进行量化。
通过使用皮肤弹性测定仪（Cutometer）和皮肤弹性评估仪（Reviscometer）测量皮肤弹性，并借助多光子激光断层扫描仪DermaInspect对真皮基质成分进行半定量评估，将使用室内晒黑设施的年轻健康志愿者和老年人与相应对照组进行比较。
我们发现，使用这三种方法均能检测到受阳光保护的掌侧前臂和背侧之间以及年轻和老年测试者之间存在差异。室内晒黑测试者的皮肤与对照组之间未发现显著差异。此外，性别对皮肤老化的严重程度没有影响。
使用DermaInspect获得的结果最为一致。由于本研究的横断面设计，个体间存在相当大的差异，这可能掩盖了晒黑床造成的实际皮肤损伤。
