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Clin Exp Immunol. 1977 Jun;28(3):467-73.
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Arthritis Res Ther. 2024 Mar 9;26(1):65. doi: 10.1186/s13075-024-03301-0.
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The effect of autologous serum, Oradexon and heparin on the cell-mediated immune response in vascular diseases.自体血清、奥沙拉秦及肝素对血管疾病中细胞介导免疫反应的影响。
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Impaired T cell capping and receptor regeneration in active systemic lupus erythematosus. Evidence for a disorder intrinsic to the T lymphocyte.活动性系统性红斑狼疮中T细胞帽化和受体再生受损。T淋巴细胞内在紊乱的证据。
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7
Immune status in Crohn's disease. 3. Peripheral blood B lymphocytes, enumerated by means of F(ab)2-antibody fragments, Null and T lymphocytes.克罗恩病中的免疫状态。3. 外周血B淋巴细胞，通过F(ab)2抗体片段计数，以及裸细胞和T淋巴细胞。
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本文引用的文献

1
Prednisolone inhibition of DNA synthesis by human lymphocytes induced in 1itro by phytohaemagglutinin.泼尼松龙对植物血凝素体外诱导的人淋巴细胞DNA合成的抑制作用。
Int Arch Allergy Appl Immunol. 1967;32(2):191-200. doi: 10.1159/000229927.
2
Transformation of lymphocytes from patients with multiple sclerosis. Use of encephalitogen of human origin, with a report of a trial of immunosuppressive therapy in multiple sclerosis.
Arch Neurol. 1970 Jul;23(1):32-40. doi: 10.1001/archneur.1970.00480250036006.
3
Thymus-derived lymphocytes and hydrocortisone: identification of subsets of theta-bearing cells and redistribution to bone marrow.胸腺来源的淋巴细胞与氢化可的松：θ 阳性细胞亚群的鉴定及其向骨髓的再分布
Cell Immunol. 1972 Sep;5(1):74-86. doi: 10.1016/0008-8749(72)90085-8.
4
Corticosteroids and lymphoid cells.皮质类固醇与淋巴细胞。
N Engl J Med. 1972 Aug 24;287(8):388-97. doi: 10.1056/NEJM197208242870806.
5
The effect of in vivo hydrocortisone on subpopulations of human lymphocytes.体内氢化可的松对人淋巴细胞亚群的影响。
J Clin Invest. 1974 Jan;53(1):240-6. doi: 10.1172/JCI107544.
6
Sequestration of PHA-responsive cells (T-lymphocytes) in the bone marrow of leukemic children undergoing long-term immunosuppressive therapy.
J Immunol. 1972 Nov;109(5):927-32.
7
The PHA dose-response curve: validation of the use of logarithmic graph paper by computer analysis results.
J Immunol. 1974 Dec;113(6):2035-9.
8
The present status of corticotrophin therapy.促肾上腺皮质激素疗法的现状。
Practitioner. 1972 Mar;208(245):329-37.
9
The effect of plasma cortisol levels on the lymphocyte transformation test.血浆皮质醇水平对淋巴细胞转化试验的影响。
J Allergy Clin Immunol. 1972 Jan;49(1):10-5. doi: 10.1016/0091-6749(72)90118-2.
10
Intermittent corticotrophin therapy. Study of lymphocyte transformation in vitro in rheumatoid arthritis.间歇性促肾上腺皮质激素疗法。类风湿关节炎体外淋巴细胞转化研究。
Ann Rheum Dis. 1969 Sep;28(5):524-8. doi: 10.1136/ard.28.5.524.

泼尼松龙和促肾上腺皮质激素急性及长期给药对淋巴细胞亚群的影响。

The effect of acute and prolonged administration of prednisolone and ACTH on lymphocyte subpopulations.

作者信息

Cooper D A, Petts V, Luckhurst E, Penny R

出版信息

Clin Exp Immunol. 1977 Jun;28(3):467-73.

PMID:196799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541023/
Abstract

The effect of acute and prolonged three week administration of prednisolone and ACTH on the numbers and function of T- and B-lymphocyte subpopulations in patients requiring corticosteroid therapy was studied. Prednisolone caused severe reduction in E-rosette-forming lymphocytes, phytohaemagglutinin response, EAC-rosette-forming lymphocytes and surface-membrane mu-positive B-lymphocytes maximal at 4--6 hr after administration with reversal sometimes to supernormal levels by 24 hr. Prolonged administration resulted in a similar pattern of response. Acute but not prolonged prednisolone administration caused a reduction in the percentage of E-rosette-forming lymphocytes maximal at 4 hr. ACTH caused moderate reduction in these parameters at 4 and 6 hr which remained low at 24 hr after prolonged administration.

摘要

研究了急性及为期三周的泼尼松龙和促肾上腺皮质激素给药对需要皮质类固醇治疗的患者T淋巴细胞和B淋巴细胞亚群数量及功能的影响。泼尼松龙导致E花环形成淋巴细胞、植物血凝素反应、EAC花环形成淋巴细胞和表面膜μ阳性B淋巴细胞严重减少，给药后4 - 6小时达到最大降幅，有时到24小时会恢复至超常水平。长期给药导致类似的反应模式。急性而非长期给予泼尼松龙会使E花环形成淋巴细胞百分比在4小时时降至最低。促肾上腺皮质激素在4小时和6小时时使这些参数适度降低，长期给药后24小时仍维持在低水平。