泼尼松龙和促肾上腺皮质激素急性及长期给药对淋巴细胞亚群的影响。
The effect of acute and prolonged administration of prednisolone and ACTH on lymphocyte subpopulations.
作者信息
Cooper D A, Petts V, Luckhurst E, Penny R
出版信息
Clin Exp Immunol. 1977 Jun;28(3):467-73.
Abstract
The effect of acute and prolonged three week administration of prednisolone and ACTH on the numbers and function of T- and B-lymphocyte subpopulations in patients requiring corticosteroid therapy was studied. Prednisolone caused severe reduction in E-rosette-forming lymphocytes, phytohaemagglutinin response, EAC-rosette-forming lymphocytes and surface-membrane mu-positive B-lymphocytes maximal at 4--6 hr after administration with reversal sometimes to supernormal levels by 24 hr. Prolonged administration resulted in a similar pattern of response. Acute but not prolonged prednisolone administration caused a reduction in the percentage of E-rosette-forming lymphocytes maximal at 4 hr. ACTH caused moderate reduction in these parameters at 4 and 6 hr which remained low at 24 hr after prolonged administration.
摘要
研究了急性及为期三周的泼尼松龙和促肾上腺皮质激素给药对需要皮质类固醇治疗的患者T淋巴细胞和B淋巴细胞亚群数量及功能的影响。泼尼松龙导致E花环形成淋巴细胞、植物血凝素反应、EAC花环形成淋巴细胞和表面膜μ阳性B淋巴细胞严重减少，给药后4 - 6小时达到最大降幅，有时到24小时会恢复至超常水平。长期给药导致类似的反应模式。急性而非长期给予泼尼松龙会使E花环形成淋巴细胞百分比在4小时时降至最低。促肾上腺皮质激素在4小时和6小时时使这些参数适度降低，长期给药后24小时仍维持在低水平。
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