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Mitochondrial metabolism of reactive oxygen species.活性氧的线粒体代谢
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Oxidative stress and experimental carcinogenesis.氧化应激与实验性致癌作用
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Rotenone neurotoxicity: a new window on environmental causes of Parkinson's disease and related brain amyloidoses.鱼藤酮神经毒性：帕金森病及相关脑淀粉样变性病环境病因的新视角
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Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease.细胞中的线粒体功能与功能障碍：其与衰老及衰老相关疾病的关联。
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Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.复合体I介导的活性氧生成：细胞色素c和NAD(P)+氧化还原状态的调节作用
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Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens.谷胱甘肽S-转移酶作为抗氧化防御因子赋予褐飞虱拟除虫菊酯抗性。
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The importance of selenium to human health.硒对人类健康的重要性。
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通过皮肤涂抹长期接触氯氰菊酯的大鼠体内氧化应激和脂质过氧化的诱导。

Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application.

作者信息

Raina Rajinder, Verma Pawan K, Pankaj N K, Prawez Shahid

机构信息

Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, R. S. Pura, Jammu-181102 (J&K), India.

出版信息

J Vet Sci. 2009 Sep;10(3):257-9. doi: 10.4142/jvs.2009.10.3.257.

DOI:10.4142/jvs.2009.10.3.257
PMID:19687627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2801130/
Abstract

Present study was undertaken to study the effect of cypermethrin on oxidative stress after chronic dermal application. The insecticide was applied dermally at 50 mg/kg body weight in different groups of Wistar rats of either sex weighing 150-200 g. Significant (p < 0.05) increase in catalase activity was observed after 30 days of exposure. However, the superoxide dismutase activity declined significantly after 60 days of exposure. The activity of glutathione peroxidase and blood glutathione levels declined significantly (p < 0.05) after 30 days of cypermethrin dermal application. However, the activity of glutathione S-transferase increased significantly (p < 0.05) in all groups after 60 days of dermal exposure. Significant increase in lipid peroxidation was observed from 30 days onwards and reached a peak after 120 days of application.

摘要

本研究旨在探讨氯氰菊酯经皮慢性应用后对氧化应激的影响。将该杀虫剂以50mg/kg体重经皮给予不同组体重为150 - 200g的Wistar大鼠，雌雄不限。暴露30天后，过氧化氢酶活性显著（p < 0.05）增加。然而，暴露60天后，超氧化物歧化酶活性显著下降。氯氰菊酯经皮应用30天后，谷胱甘肽过氧化物酶活性和血液中谷胱甘肽水平显著（p < 0.05）下降。然而，经皮暴露60天后，所有组中谷胱甘肽S - 转移酶活性显著（p < 0.05）增加。从30天起观察到脂质过氧化显著增加，并在应用120天后达到峰值。