突尼斯健康人群血液中赭曲霉毒素A的测定。
Estimation of Ochratoxin A in human blood of healthy Tunisian population.
作者信息
Karima Hmaissia-Khlifa, Ridha Ghali, Zied Aouni, Chekib Mazigh, Salem Machgoul, Abderrazek Hedhili
机构信息
Department of Biochemistry, Military Hospital of Tunis, Montfleury, Tunis 1008, Tunisia.
出版信息
Exp Toxicol Pathol. 2010 Sep;62(5):539-42. doi: 10.1016/j.etp.2009.07.005. Epub 2009 Aug 20.
Human exposure to Ochratoxin A (OTA) has been investigated in many Mediterranean countries, where OTA was found with a higher frequency in foodstuffs and blood samples. The aim of this study was to assess OTA concentrations in human blood serum in Tunisia and to evaluate the impact of several factors (age, origin, sex) on these prevalence reference values. One hundred and seven blood serum samples from healthy subjects were analyzed using a solid-phase extraction linked to a high-performance liquid chromatography (HPLC) method. OTA values ranged from 0 to 3.43 ng/mL with a mean value of 0.49+/-0.67 ng/mL. OTA levels were higher in the Sahal group. Our results reflect OTA concentration previously detected for human blood in Tunisia. Origin, but not age and sex, may affect the OTA reference values.
许多地中海国家都对人类接触赭曲霉毒素A（OTA）的情况进行了调查，在这些国家的食品和血液样本中发现OTA的频率较高。本研究的目的是评估突尼斯人血清中的OTA浓度，并评估几个因素（年龄、籍贯、性别）对这些流行参考值的影响。使用与高效液相色谱（HPLC）方法联用的固相萃取法对107份来自健康受试者的血清样本进行了分析。OTA值范围为0至3.43 ng/mL，平均值为0.49±0.67 ng/mL。撒哈拉地区组的OTA水平较高。我们的结果反映了突尼斯此前检测到的人类血液中的OTA浓度。籍贯而非年龄和性别可能会影响OTA参考值。
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