Department of Nutritional Science and Toxicology, University of California, Berkeley, California 9472, USA.
Trends Endocrinol Metab. 2009 Nov;20(9):424-8. doi: 10.1016/j.tem.2009.06.002. Epub 2009 Sep 30.
Lipolysis for the provision of fatty acids (FA) for other organs during times of energy demand occurs uniquely in white adipose tissue (WAT). Recent findings have identified a bona fide TAG hydrolase and the major adipose phospholipase A(2), AdPLA. By controlling PGE(2) levels, AdPLA dominantly regulates lipolysis in an autocrine/paracrine manner. Moreover, recent findings demonstrate that, surprisingly, increasing lipolysis in adipose tissue does not necessarily increase serum FA levels, which are usually correlated with insulin resistance. Rather, increasing lipolysis in adipose tissue causes a shift within adipocytes towards increased FA utilization and energy expenditure and thus protects against obesity. Here, we discuss the regulation of lipolysis and its effects on FA utilization within WAT and on insulin resistance.
在能量需求时，脂肪组织（WAT）特有的脂解作用将脂肪酸（FA）供给其他器官。最近的研究发现了一种真正的 TAG 水解酶和主要的脂肪组织磷酸酶 A2（AdPLA）。通过控制 PGE2 水平，AdPLA 以自分泌/旁分泌方式主导脂解作用。此外，最近的研究发现，令人惊讶的是，增加脂肪组织中的脂解作用不一定会增加血清 FA 水平，而血清 FA 水平通常与胰岛素抵抗相关。相反，增加脂肪组织中的脂解作用会导致脂肪细胞内 FA 利用和能量消耗增加，从而防止肥胖。在这里，我们讨论了脂肪组织中脂解作用的调节及其对 FA 利用和胰岛素抵抗的影响。
